Vol. 4 No. 2 (2023): JOURNAL OF CARDIORESPIRATORY RESEARCH
Subject of the article
HEREDITARY PREDISPOSITION THEORY AND THE PROBLEM OF RHEUMATOID ARTHRITIS COMORBIDITY IN PATIENTS WITH CARDIOVASCULAR DISEASE (17-21)
Authors
Saidova Mukhabbat Mukhidinovna
Institution
Bukhara State Medical Institute
Abstract
The problem of comorbidity is widely discussed in the current medical literature. Its role in rheumatic diseases is particularly interesting because of its multifactorial nature and the involvement of a wide range of pathogenetic mechanisms. For many years, researchers around the world have noted correlations between the presence of active autoimmune disorders and the complicated course of cardiovascular diseases. A better understanding of the pathogenetic mechanisms at the current stage of rheumatology allows a new perspective on the relationship between atherosclerosis and rheumatoid arthritis. The definition of multimorbidity developed in recent years and the results of recent scientific research can contribute to a more correct choice of management tactics for patients with a combination of these two diseases.
Key words
comorbidity; multimorbidity; rheumatoid arthritis; cardiovascular disease; atherosclerosis, autoimmunity, autoinflammation
Literature
Agca R., Heslinga S.C., Rollefstad S. (2017) EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of infl ammatory joint 2. disorders: 2015/2016 update. Ann Rheum Dis., 76 (1), pp. 17–28. 3. Piepoli M.F, Hoes A.W, Agewall S, Albus C, Brotons C. (2016) 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and byinvited experts). Europ Heart J, 37(29), pp. 2315–2381. 4. Arida A., Protogerou A.D., Kitas G.D., Sfi kakis P.P. (2018) Systemic Infl ammatory Response and Atherosclerosis: The Paradigm of Chronic Infl ammatory Rheumatic Diseases. Int J Mol Sci., 19 (7),p. 1890. 5. Francula-Zaninovic S., Nola I.A. (2018) Management of Measurable Variable Cardiovascular Disease Risk Factors. Curr Cardiol Rev., 14 (3), pp. 153–163. 6. Cooney M.T, Vartiainen E, Laatikainen T, De Bacquer D, McGorrian C.(2012) Cardiovascular risk age: concepts and practicalities. Heart, 98, pp. 941–946. 7. England B.R., Thiele G.M., Anderson D.R., Mikuls T.R. (2018) Increased cardiovascular risk inrheumatoid arthritis: mechanisms and implications. BMJ, 23, p. 361. 8. Berger J.S., Jordan C.O., Lloyd-Jones D., Blumenthal R.S.(2010) Screening for Cardiovascular Risk in Asymptomatic Patients J Am Coll Cardiol, 55, pp. 1169–77. 9. Karmali K.N., Persell S.D., Perel P. (2017) Risk scoring for the primary prevention of cardiovascular disease. Cochrane Database of Systematic Reviews, issue 3. Art. No.: CD00688. 10. Kamilova U.K, Saidova M.M.(2019) Assessment of Cardiovascular Risk in Patients with Rheumatoid Arthritis Journal of "Cardiology in Belarus", 2019, volume 11, № 4, pp. 614–619 11. Willis A., Davies M., Yates T., Khunti K. (2012) Primary prevention of cardiovascular disease using validated risk scores: a systematic review. Journal of Royal Society of Medicine, 105 (8), pp. 348–56. Yfc`S^ ]ScW[acXdb[cSeac`nh[dd^XWaUS`[\¬ ɮɹɮɖɮɮɹ№2 | 2023 12. Crowson C.S., Gabriel Sh.E., Semb A.G. (2018) Rheumatoid arthritis-specifi c cardiovascular risk scores are not superior to general risk scores: a validation analysis of patients from seven 13. countries. Swiss Med Wkl, 22, p. 148. 14. Mukhidinovna, Saidova M., and Khamroeva Y. Saidovna. "Cardiovascular Risk in Patients with Systemic Sclerodermia." International Journal on Orange Technologies, vol. 3, no. 3, 2021, pp. 45-49, doi:10.31149/ijot.v3i3.1371. 15. Rustamovich U. J. LARYNCH DEFECT IN RHEUMATOID ARTHRITIS //Gospodarka i Innowacje. – 2022. – Т. 28. – С. 198-201. 16. Мустафаева Ш. А. Функционально-Морфологическое Состояние Клеток Почек У Больных Ревмотоидным Артритом //AMALIY VA TIBBIYOT FANLARI ILMIY JURNALI. – 2022. – Т. 1. – №. 4. – С. 22-27. 17. Саидова М. М. ОЦЕНКА ПАРАМЕТРОВ ТОЛЩИНЫ ИНТИМА-МЕДИА СОННЫХ АРТЕРИЙ КАК РАННЕГО ПРЕДИКТОРА РАЗВИТИЯ АТЕРОСКЛЕРОЗА У БОЛЬНЫХ РЕВМАТОИДНЫМ АРТРИТОМ //Журнал кардиореспираторных исследований. – 2022. – Т. 3. – №. 1. 18. 16 Саидова М.М., Камилова У.К. СЕРДЕЧНО-СОСУДИСТЫЙ РИСК ПО ШКАЛЕ MSCORE У БОЛЬНЫХ РЕВМАТОИДНЫМ АРТРИТОМ // ЕКЖ. 2019. №S1. URL: https://cyberleninka.ru/article/n/serdechno-sosudistyy-risk-po-shkale-mscore-u-bolnyhrevmatoidnym-artritom (дата обращения: 25.11.2022). 19. Саидова М. М., Камилова У. К. Анализ встречаемости кардиоваскулярной коморбидности у больных ревматоидным артритом //Артериальная гипертония 2017 как междисциплинарная проблема. – 2017. – С. 41-42. 20. Саидова М. М., Хамроева Ю. С. СЕРДЕЧНО-СОСУДИСТЫЙ РИСК У БОЛЬНЫХ СИСТЕМНОЙ СКЛЕРОДЕРМИЕЙ //Новый день в медицине. – 2021. – №. 1. – С. 265-269. 21. Ташкенбаева Э. Н. и др. Хроническая сердечная недостаточность как ведущая медико-социальная и экономическая проблема //Journal of cardiorespiratory research. – 2021. – Т. 1. – №. 3. – С. 18-21. 22. Ташкенбаева Э. и др. Маркеры гиперурикемии как фактор риска и предикторы сердечно-сосудистых заболеваний //Журнал проблемы биологии и медицины. – 2016. – №. 2 (87). – С. 191-194.