Журнал кардиореспираторных исследований 2023. №1
Subject of the article
SURUNKALI YURAK ISHEMIK KASALLIGI BO'LGAN BEMORLARDA NEYTROFILLAR DARAJASINING PERIODONT HOLATIGA BOG'LIQLIGI (9-13)
Authors
Agababyan I.R., Kobilova N.A., Nurmatov O.S.
Institution
Самаркандский государственный медицинский университет
Abstract
Yurak-qon tomir kasalliklarining asosiy sababi aterosklerozdir. Ateroskleroz - surunkali yallig'lanishli tomir kasalligi bo'lib, arteria devorida lipid pilakchalarning cho'kishiga olib keladi. Ushbu pilakchalarning to'planishi va rivojlanishi qon oqimini kamaytirishi mumkin, bu esa barcha organlar va to'qimalarning ishemiyasiga olib keladi, shuningdek, tromb shakllanishiga yordam beradi. Ateroskleroz bilan bog'liq bo'lgan asosiy yurak kasalliklariga miokard infarkti, o'tkir koronar sindrom, yurak etishmovchiligi, aritmiya va kardiyomiyopatiya kiradi. Dunyo bo'yicha yurakqon tomir kasalliklari birinchi o'rinni egallaydi va o'limning asosiy sababidir. Ateroskleroz surunkali yallig'lanish kasalligi bo'lganligi sababli, tadqiqotchilar boshqa yallig'lanish holatlari aterosklerozga hissa qo'shishi va kasallikning kechishini yomonlashtirishi mumkinligini tushunishga harakat qilishdi. Kam o'rganilgan yallig'lanish kasalliklaridan biri parodontit bo'lgan.. Ba'zi tadqiqotlarga ko'ra, har xil turdagi blyashka natijasida paydo bo'lgan periodontal kasallik (shu jumladan gingivit, AQShda 30 yosh va undan katta yoshdagi kattalar aholisining 47,2 foiziga ta'sir qiladi. 65 yoshdan keyin bu ko'rsatkich 70% gacha oshadi. Og'iz bo'shlig'ini parvarish qilish odatlaridan tashqari, periodontal kasallikka hissa qo'shadigan omillar orasida ijtimoiy-iqtisodiy holat, jins va chekish kiradi. Periodontit dunyoda barcha kasalliklar orasida oltinchi o'rinda turadi. Periodontit bilan birgalikda aterosklerozli bemorlarda yallig'lanishni saqlab qolishda muhim rol o'ynaydigan neytrofillarning roli haqidagi ushbu maqola o'rganilmagan muammolar pardasini biroz ochadi.
Key words
аterosklerotik yurak-qon tomir kasalliklari, periodontit, neytrofillar, yallig'lanishga qarshi sitokinlar, giperurikemiya.
Literature
Agababyan I. R., Ismailov Zh. A., Adilov A. S. Inflammation of adipose tissue is the main predictor in the development of arterial hypertension in patients with metabolic syndrome // Achievements of science and education. – 2020. – no. 3 (57). - S. 88-91. 2. Ризаев Э. А., Агабабян И. Р., Арзикулова М. Ш. К. АУТОИММУННОЕ ВОСПАЛЕНИЕ КАК ПРИЧИННО-СЛЕДСТВЕННАЯ СВЯЗЬ ПАРОДОНТИТА И АТЕРОСКЛЕРОЗА //Вопросы науки и образования. – 2022. – №. 6 (162). – С. 50-64. 3. Agababyan, I. R., and Ruziyeva AA. "Тhe diagnostic value of routine research methods electrocardiography and echocardiography in patients with chronic heart failure elderly." International Conference «Process Management and Scientific Developments. 2019. 4. Alard J-E, Ortega-Gomez A, Wichapong K, Bongiovanni D, Horckmans M, Megens RT, et al. Recruitment of Classical Monocytes Can be Inhibited by Disturbing Heteromers of Neutrophil HNP1 and Platelet CCL5. Sci Transl Med (2018) 7(317):317ra196-317ra196. doi: 10.1126/scitranslmed.aad5330 5. Alisherovna K. M., Akmalovna K. N., Mamasoliyevna D. N. Kidney dysfunction in chronic heart failure //Texas Journal of Medical Science. – 2022. – Т. 13. – С. 104-109. 6. Alimdjanovich R. J., Rubenovna A. I., Abduvokhidovna I. Y. SPECIALIZED CENTER FOR THE PATIENTS WITH CHRONIC HEART FAILURE-EXTENSION OF LIFE //Вопросы науки и образования. – 2021. – №. 22 (147). – С. 14-24. 7. Counteracts Chemokine-induced Arterial Myeloid Cell Recruitment. Circ Res (2018) 116(5):827-35. doi: 10.1161/CIRCRESAHA.116.305825 8. Disease: a Review of Initiators and Protective Factors. Inflammopharmacology (2016) 24(1):1- 10. doi: 10.1007/s10787-015-0255-y 9. Hajishengallis G, Chavakis T. Local and Systemic Mechanisms Linking Periodontal Disease and Inflammatory Comorbidities. Nat Rev Immunol (2021) 21(7):426-440. doi: 0.1038/s41577- 020-00488-6 10. Herrera D, Molina A, Buhlin K, Klinge B. Periodontal diseases and association with atherosclerotic disease. Periodontol 2000 (2020) 83(1):66-89. doi: 10.1111/prd.12302 11. Irina, Agababyan, Sitora Soliyeva, and Yulduz Ismoilova. "Condition of Coronary Arteries and Change of Lipid Profile in Coronary Heart Disease." Annals of RSCB, ISSN: 1583-6258. 12. Kinane DF, Stathopoulou PG, Papapanou PN. Periodontal Diseases. Nat Rev Dis Primers (2017) 3(1):17038. doi: 10.1038/nrdp.2017.38 13. Kobilova N. A., Jabbarova N. M. Effect of cardioprotectors on quality of life of patients with ischemic heart disease complicated with chronic heart failure // journal of biomedicine and practice. – 2022. – т. 7. – №. 1. 14. Kobilova n. Trimetazidine in combined therapy of ischemic heart disease with myocardial infarction // journal of cardiorespiratory research. -2021-т.2.-№.4.-с. 31-33. 15. Konkel JE, O'Boyle C, Krishnan S. Distal Consequences of Oral Inflammation. Front Immunol (2019) 10:1403. doi: 10.3389/fimmu.2019.01403 16. Libby P. The Biology of Atherosclerosis Comes Full Circle: Lessons for Conquering Cardiovascular Disease. Nat Rev Cardiol (2021) 18(10):683-4. doi: 10.1038/s41569-021- 00609-1 17. Loos BG, Van Dyke TE. The Role of Inflammation and Genetics in Periodontal Disease. Periodontol 2000 (2020) 83(1):26-39. doi: 10.1111/prd.12297