Биология ва тиббиёт муаммолари 2024 №4 (155)

Maqola mavzusi

СВЯЗЬ НЕЙРОДЕГЕНЕРАТИВНЫХ ЗАБОЛЕВАНИЙ С ЭНТЕРОВИРУСНОЙ ИНФЕКЦИЕЙ (489-493)

Mualliflar

Ярмухамедова Наргиза Анваровна, Маллаходжаев Анвархон Адибхонович

Muassasa

Самаркандский государственный медицинский университет, Республика Узбекистан, г. Самарканд

Annotatsiya

В течение последнего десятилетия во многих странах мира наметилась четкая тенденция к увеличению случаев частоты встречаемости энтеровирусной инфекции, о чем свидетельствуют регистрируемые во многих странах эпидемические подъемы и вспышки наиболее манифестных клинических форм этого заболевания. География ЭВИ чрезвычайно широка и охватывает все страны мира, в том числе и постсоветского пространства. Они связаны в основ-ном с метаболизмом белков и структурными измене-ниями, что приводит к гибели нейронных клеток. Ви-русные инфекции влияют на эти клеточные процессы и могут стать этиологическим фактором неврологи-ческих заболеваний. Энтеровирусы (ЭВ) часто пора-жают центральную нервную систему (ЦНС). В связи с этим мы обсуждаем самые последние результаты по этому вопросу, изучая возможную роль ЭВ в развитии НДЗ.

Kalit so'zlar

энтеровирус; нейродегенеративные заболевания; боковой амиотрофический склероз; болезнь Альцгеймера; болезнь Паркинсона.

Adabiyotlar

1. Dugger BN, Dickson DW. Pathology of neurodegener-ative diseases. Cold Spring Harb Perspect Biol. 2017; 9(7): a028035. 2. Guzman-Martinez L, Maccioni RB, Andrade V, Navarrete LP, Pastor MG, Ramos-Escobar N. Neuroinflammation as a common feature of neurodegenerative disorders. Front Pharmacol. 2019; 12(10): 1008. 3. Chen WW, Zhang X, Huang WJ. Role of neuroinflammation in neurodegenerative diseases (Re-view). Mol Med Rep. 2016; 13(4): 3391-6. 4. Soto C, Pritzkow S. Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases. Nat Neurosci. 2018; 21(10): 1332-40. 5. Migliore L, Coppedè F. Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases. Mutat Res. 2009; 667(1-2): 82-97. 6. Onisiforou A, Spyrou GM. Identification of viral-mediated pathogenic mechanisms in neurodegenerative diseases using network-based approaches. Brief Bioinform. 2021; 22(6): bbab141. 7. Abbott A. Are infections seeding some cases of Alz-heimer's disease? Nature. 2020; 587(7832): 22-5. 8. Lotz SK et al Microbial infections are a risk factor for neurodegenerative diseases. Front Cell Neurosci. 2021; 7(15): 691136. 9. Wouk J, Rechenchoski DZ, Rodrigues BCD, Ribelato EV, Faccin-Galhardi LC. Viral infections and their rela-tionship to neurological disorders. Arch Virol. 2021; 166(3): 733-53. 10. Даминов Ж. Н. и др. “Сравнительное Изучение Биологических Свойств Стафилококков, Выделенных От Здоровых Носителей И При Различных Клинических Формах Инфекций”. Central Asian Journal of Medical and Natural Science 3, no. 3 (May 21, 2022): 148-150. 11. Feruza, Abdusalomova, Yusupov Bobur, Mallakhodzhaev Anvarkhon, and Yusupov Temurbek. “Clinical Significance of Nosocomial Infections in a Hos-pital Setting”. Middle European Scientific Bulletin 27 (August 18, 2022): 37-41 12. Leblanc P, Vorberg IM. Viruses in neurodegenerative diseases: more than just suspects in crimes. PLoS Pathog. 2022 13. Follmer C. Viral infection-induced gut dysbiosis, neuroinflammation, and a-synuclein aggregation updates and perspectives on COVID-19 and neurodegenerative disorders. ACS Chem Neurosci. 2020;11(24):4012–4016 14. Fang P, Kazmi SA, Jameson KG, Hsiao EY. The microbiome as a modifier of neurodegenerative disease risk. Cell Host Microbe. 2020;28(2):201–222 15. Chopra G, Shabir S, Yousuf S, Kauts S, Bhat SA, Mir AH, et al. Proteinopathies: deciphering physiology and mechanisms to develop effective therapies for neurodegenerative diseases. Mol Neurobiol. 2022; 59: 7513-40. 16. Rizaev J. A., Sh A. M. COVID-19 views on immuno-logical aspects of the oral mucosa //European research: innovation in science, education and technology. – 2022. – С. 111-113. 17. Rizaev J. A. et al. Physico-chemical parameters of mixed saliva and their correction in patients in the post-covid period // Cardiometry. – 2022. – №. 25. – С. 1168-1173. 18. Rizaev J. A., Tuxtarov B. E., Tulaganov B. B. Improv-ing the prevention of occupational diseases among dentists // British Medical Journal. – 2022. – Т. 2. – №. 5. 19. Rizaev J., Usmanbekova G., Nurmamatova Q. Some Issues of Prospective Planning of the Activity of Second-ary Medical Staff in the Dental Service in the Republic of Uzbekistan // Annals of the Romanian Society for Cell Biology. – 2021. – С. 308-314. 20. Rizaev J. A. Features of the aggressive forms of perio-dontitis course //International Journal of Bio-Science and Bio-Technology. – 2019. – Т. 11. – №. 7. – С. 10-16. 21. Hategan A, Bianchet MA, Steiner J, Karnaukhova E, Masliah E, Fields A, et al. HIV Tat protein and amyloid-ß peptide form multifibrillar structures that cause neurotoxi-city. Nat Struct Mol Biol. 2017; 24(4): 379-86. 22. Tetz G, Pinho M, Pritzkow S, Mendez N, Soto C, Tetz V. Bacterial DNA promotes Tau aggregation. Sci Rep. 2020; 10(1): 2369. 23. Hara H, et al. Neurotropic influenza A virus infection causes prion protein misfolding into infectious prions in neuroblastoma cells. Sci Rep. 2021; 11(1): 10109. 24. Angelli JN, Passos YM, Brito JMA, Silva JL, Cordeiro Y, Vieira TCRG. Rabbit PrP is partially resistant to in vitro aggregation induced by different biological cofactors. Front Neurosci. 2021; 15: 689315. 25. Silva JL, Cordeiro Y. The "Jekyll and Hyde" actions of nucleic acids on the prion-like aggregation of proteins. J Biol Chem. 2016; 291(30): 15482-90. 26. Tetz G, Tetz V. Bacterial extracellular DNA promotes ß-amyloid aggregation. microorganisms. 2021; 9(6): 1301. 27. Riek R, Eisenberg DS. The activities of amyloids from a structural perspective. Nature. 2016; 539(7628): 227-35. 28. De-Paula VJ, Radanovic M, Diniz B, Forlenza O. Alz-heimer's disease. In: Harris J, editor. Protein aggregation and fibrillogenesis in cerebral and systemic amyloid dis-ease. Subcellular Biochemistry. Vol 65. Dordrecht: Springer; 2012. 29. Wozniak MA, Frost AL, Itzhaki RF. Alzheimer's dis-ease-specific tau phosphorylation is induced by herpes simplex virus type 1. J Alzheimers Dis. 2009; 16: 341-50. 30. Zambrano A, Solis L, Salvadores N, Cortés M, Lerchundi R, Otth C. Neuronal cytoskeletal dynamic modification and neurodegeneration induced by infection with herpes simplex virus type 1. J Alzheimers Dis. 2008; 14(3): 259-69. 31. Wozniak MA, Frost AL, Preston CM, Itzhaki RF. An-tivirals reduce the formation of key Alzheimer's disease molecules in cell cultures acutely infected with herpes simplex virus type 1. PLoS One. 2011; 6(10): e25152.