Биология ва тиббиёт муаммолари 2024 №2 (152)

Maqola mavzusi

АЛЛЕРГИЧЕСКИЙ РИНИТ – ПРОБЛЕМА ЭКОЛОГИЧЕСКОЙ КАТАСТРОФЫ ИЛИ ПАТОФИЗИОЛОГИЧЕСКИХ ИЗМЕНЕНИЙ ОРГАНИЗМА (335-343)

Mualliflar

Ирсалиева Фотима Хусниддиновна, Рузикулов Азамат Курбанмурадович

Muassasa

1 - Ташкентская Медицинская Академия, Республика Узбекистан, г. Ташкент; 2 – Термезский филиал Ташкентской медицинской академии, Республика Узбекистан, г. Термез

Annotatsiya

Целью данного обзора было – изучить результаты многоцентровых исследований, посвященных проблеме аллергического ринита, определить степень взаимосвязи заболевания с экологическими катаклизмами, интерпретируя результаты влияния их на основные патофизиологические изменения организма основываясь на заключения, научно обоснованные данные протоколов различных исследователей. В надежде на то, чтобы глубже проникнуть в суть раз-вития аллергического ринита у пациентов, тем более у живущих и работающих в экологически неблагоприятных условиях будем настойчиво проводить исследования в направлении понятия изменений патофизиологических дисфункций организма при подобном состоянии. И нужно отметить, что можно долго анализировать состояние аллергизации организма с клиническими проявлениями АР, однако задачей врача-аллерголога является изучение, выявление причин и клинического течения заболевания, и как можно скорее начать целенаправленную, патогенетически обоснованную терапию, проводить профилактику возможных обострений и осложнений данного состояния.

Kalit so'zlar

аллергический ринит, этиология, эпидемиология, диагностические критерии, лабораторные признаки, клинические симптомы, патофизиология аллергического ринита.

Adabiyotlar

1. Терехова Е.П., Терехов Д.В. Аллергический ринит: современные методы терапии // Бронхопульмонология, ЛОР, Аллергология 10.21518/2079-701x-2016, №17. – С.74-79. 2. Аллергология. Федеральные клинические реко мендации. Под ред. Р.М. Хаитова, Н.И. Ильиной. М.: Издательство «ФАРМАРУС ПРИНТ МЕДИА», 2014, глава Аллергический ринит: 20-34. 3. Meltzer EO et al. Sleep, quality of life, and pro ductivity impact of nasal symptoms in the United States: findings from the Burden of Rhinitis in American survey. Allergy Asthma Proc, 2009, 30(3): 244-54. 4. Dykewicz MS, Hamilos DL. Rhinitis and sinusitis. J Allergy ClinImmunol, 2010, 125(2 Suppl. 2). 5. Wallace DV et al. Joint Task Force on Practice; American Academy of Allergy; Asthma & Immunology; American College of Allergy; Asthma and Immunology; Joint Council of Allergy, Asthma and Immunology. The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin. Immunol, 2008, 122(Suppl. 2): 1084. 6. Bjermer et al. Allergy Asthma Clin Immunol (2019) 15:24 https://doi.org/10.1186/s13223-018-0314-1 7. Bousquet J et al. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy, 2008, 63(Suppl. 86): 8-160. 8. Eriksson J, Ekerljung L, Ronmark E, Dahlen B, Ahlstedt S, Dahlen SE, et al. Update of prevalence of self-reported allergic rhinitis and chronic nasal symptoms among adults in Sweden. Clin Respir J. 2012;6(3):159–68 9. Skoner DP. Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis. J Allergy Clin Immunol. (2001) 108(Suppl. 1):S2–8. doi: 10.1067/mai.2001.115569 10. Wheatley LM, Togias A. Clinical practice. Allergic rhinitis. N Engl J Med. (2015) 372:456–63. doi: 10.1056/NEJMcp1412282 11. Hill DA, Grundmeier RW, Ram G, Spergel JM. The epidemiologic characteristics of healthcare provider-diagnosed eczema, asthma, allergic rhinitis, and food allergy in children: a retrospective cohort study. BMC Pediatr. (2016) 16:133. doi: 10.1186/s12887-016-0673-z 12. Frohlich M, Pinart M, Keller T, Reich A, Cabieses B, Hohmann C, et al. Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis. Clin Transl Allergy. (2017) 7:44. doi: 10.1186/s13601-017-0176-5 13. Pinart M, Keller T, Reich A, Frohlich M, Cabieses B, Hohmann C, et al. Sex-related allergic rhinitis prevalence switch from childhood to adulthood: a systematic review and meta-analysis. Int Arch Allergy Immunol. (2017) 172:224–35. doi: 10.1159/000464324 14. Valovirta E, Myrseth SE, Palkonen S. The voice of the patients: allergic rhinitis is not a trivial disease. Curr Opin Allergy Clin Immunol. 2008;8(1):1–9. 15. Walker S, Khan-Wasti S, Fletcher M, Cullinan P, Harris J, Sheikh A. Seasonal allergic rhinitis is associated with a detrimental efect on examination performance in United Kingdom teenagers: case–control study. J Allergy Clin Immunol. 2007;120(2):381–7 16. Benninger MS, Benninger RM. The impact of allergic rhinitis on sexual activity, sleep, and fatigue. Allergy Asthma Proc. 2009;30(4):358–65 17. Braido F, Baiardini I, Scichilone N, Musarra A, Menoni S, Ridolo E, et al. Illness perception, mood and coping strategies in allergic rhinitis: are there diferences among ARIA classes of severity? Rhinology. 2014;52(1):66–71 18. Vuurman EF, Vuurman LL, Lutgens I, Kremer B. Allergic rhinitis is a risk factor for trafc safety. Allergy. 2014;69(7):906–12. 19. Brozek JL, Bousquet J, Agache I, Agarwal A, Bachert C, BosnicAnticevich S, et al. Allergic rhinitis and its impact on asthma (ARIA) guidelines—2016 revision. J Allergy Clin Immunol. 2017;140(4):950–8. 20. Brozek JL, Bousquet J, Baena-Cagnani CE, Bonini S, Canonica GW, Casale TB, et al. Allergic rhinitis and its impact on asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol. 2010;126(3):466–76 21. Siti Sarah COS, Shukri NM, Ashari NSM, Wong KK. Zonula occludens and nasal epithelial barrier integrity in allergic rhinitis. PeerJ. (2020) 8:e9834. doi: 10.7717/peerj.9834 22. Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the world health organization, GA(2)LEN and AllerGen). Allergy. (2008) 63(Suppl. 86):S8–160. doi: 10.1111/j.1398-9995.2007.01620.x 23. Горячкина Л.А., Дробик О.С., Насунова А.Ю. Поллинозы: современный взгляд на проблему. Вестник семейной медицины, 2012, 1: 10-16. 24. Steelant B, Farre R, Wawrzyniak P, Belmans J, Dekimpe E, Vanheel H, et al. Impaired barrier function in patients with house dust mite-induced allergic rhinitis is accompanied by decreased occludin and zonula occludens1 expression. J Allergy Clin Immunol. (2016) 137:1043–53.e5. doi: 10.1016/j. jaci.2015.10.050 25. Steelant B, Seys SF, Boeckxstaens G, Akdis CA, Ceuppens JL, Hellings PW. Restoring airway epithelial barrier dysfunction: a new therapeutic challenge in allergic airway disease. Rhinology. (2016) 54:195–205. doi: 10.4193/Rhin15. 376 26. Steelant B, Seys SF, Van Gerven L, Van Woensel M, Farre R, Wawrzyniak P, et al. His-tamine and T helper cytokine-driven epithelial barrier dysfunction in allergic rhinitis. J Allergy Clin Immunol. (2018) 141:951–63.e8. doi: 10. 1016/j.jaci.2017.08.039 27. Nur Husna SM, Tan H-TT, Md Shukri N, Mohd Ashari NS, Wong KK. Nasal epithelial barrier integrity and tight junctions disruption in allergic rhinitis: overview and pathogenic insights. Front Immunol. (2021) 12:663626. doi: 10.3389/fimmu.2021.663626 28. Nur Husna SM, Siti Sarah CO, Tan HT, Md Shukri N, Mohd Ashari NS, Wong KK. Reduced occludin and claudin-7 expression is associated with urban locations and exposure to second-hand smoke in allergic rhinitis patients. Sci Rep. (2021) 11:1245. doi: 10.1038/s41598-020-79208-y 29. Siti Sarah COS, Shukri NM, Ashari NSM, Wong KK. Zonula occludens and nasal epithelial barrier integrity in allergic rhinitis. PeerJ. (2020) 8:e9834. doi: 10.7717/peerj.9834 30. Singh S, Sharma BB, Salvi S, Chhatwal J, Jain KC, Kumar L, et al. Allergic rhinitis, rhinoconjunctivitis, and eczema: prevalence and associated factors in children. Clin Respir J. (2018) 12:547–56. doi: 10.1111/crj. 12561 31. Chung SJ, Kim BK, Oh JH, Shim JS, Chang YS, Cho SH, et al. Novel tobacco products including electronic cigarette and heated tobacco products increase risk of allergic rhinitis and asthma in adolescents: analysis of Korean youth survey. Allergy. (2020) 75:1640–8. doi: 10.1111/all.14212 32. Gangwar RS, Friedman S, Seaf M, Levi-Schaffer F. Mast cells and eosinophils in allergy: close friends or just neighbors. Eur J Pharmacol. (2016) 778:77–83. doi: 10.1016/j.ejphar.2015.10.036 33. Nur Husna SM, Tan H-TT, Md Shukri N, Mohd Ashari NS, Wong KK. Nasal epithelial barrier integrity and tight junctions disruption in allergic rhinitis: overview and pathogenic insights. Front Immunol. (2021) 12:663626. doi: 10.3389/fimmu.2021.663626, 34. Tan H-TT, Sugita K, Akdis CA. Novel biologicals for the treatment of allergic diseases and asthma. Curr Allergy Asthma Rep. (2016) 16:70. doi: 10.1007/ s11882-016-0650-5 35. Sani MM, Ashari NSM, Abdullah B, Wong KK, Musa KI, Mohamud R, et al. Reduced Cd4+ terminally differentiated effector memory T cells in moderatesevere house dust mites sensitized allergic rhinitis patients. Asian Pac J Allergy Immunol. (2019) 37:138–46. doi: 10.12932/AP-191217-0220 36. Cardell LO, Olsson P, Andersson M, Welin KO, Svensson J, Tennvall GR, et al. TOTALL: high cost of allergic rhinitis—a national Swedish population-based questionnaire study. NPJ Prim Care Respir Med. 2016;26:15082. 37. Cardell LO, Olsson P, Andersson M, Welin KO, Svensson J, Tennvall GR, et al. TOTALL: high cost of allergic rhinitis—a national Swedish population-based questionnaire study. NPJ Prim Care Respir Med. 2016;26:15082 38. Lamb CE, Ratner PH, Johnson CE, Ambegaonkar AJ, Joshi AV, Day D, et al. Economic impact of workplace productivity losses due to allergic rhinitis compared with select medical conditions in the United States from an employer perspective. Curr Med Res Opin. 2006;22(6):1203–10 39. Elholm G, Linneberg A, Husemoen LL, Omland O, Gronager PM, Sigsgaard T, et al. The Danish urban-rural gradient of allergic sensitization and disease in adults. Clin Exp Allergy. (2016) 46:103–11. doi: 10.1111/cea.12583 40. Li CW, Chen DD, Zhong JT, Lin ZB, Peng H, Lu HG, et al. Epidemiological characterization and risk factors of allergic rhinitis in the general population in Guangzhou city in China. PLoS One. (2014) 9:e114950. doi: 10.1371/ jour-nal.pone.0114950) 41. Wang IJ, Tung TH, Tang CS, Zhao ZH. Allergens, air pollutants, and childhood allergic diseases. Int J Hyg Environ Health. (2016) 219:66–71. doi: 10.1016/j.ijheh.2015.09.001 42. Leung TF, Ko FW, Wong GW. Roles of pollution in the prevalence and exacerbations of allergic diseases in Asia. J Allergy Clin Immunol. (2012) 129:42–7. doi: 10.1016/j.jaci.2011.11.031 21. D’Amato G, Akdis C. Global warming, climate change, air pollution and allergies. Allergy. (2020) 75:2158–60. doi: 10.1111/all.14527 43. Singh S, Sharma BB, Salvi S, Chhatwal J, Jain KC, Kumar L, et al. Allergic rhinitis, rhinoconjunctivitis, and eczema: prevalence and associated factors in children. Clin Respir J. (2018) 12:547–56. doi: 10.1111/crj. 12561 44. Chung SJ, Kim BK, Oh JH, Shim JS, Chang YS, Cho SH, et al. Novel tobacco products including electronic cigarette and heated tobacco products increase risk of allergic rhinitis and asthma in adolescents: analysis of Korean youth survey. Allergy. (2020) 75:1640–8. doi: 10.1111/all.14212 45. Castelli S, Arasi S, Tripodi S, Villalta D, Martelli P, Conte M, et al. Ige antibody repertoire in nasal secretions of children and adults with seasonal allergic rhinitis: a molecular analysis. Pediatr Allergy Immunol. (2020) 31:273–80. doi: 10.1111/pai.13148 46. Garib V, Rigler E, Gastager F, Campana R, Dorofeeva Y, Gattinger P, et al. Determination of Ige and Igg reactivity to more than 170 allergen molecules in paper-dried blood spots. J Allergy Clin Immunol. (2019) 143:437–40. doi: 10.1016/j.jaci.2018.08.047 47. Tanno LK, Calderon MA, Li J, Casale T, Demoly P, Joint Allergy A. Updating allergy and/or hypersensitivity diagnostic procedures in the WHO ICD-11 revision. J Allergy Clin Immunol Pract. (2016) 4:650–7. doi: 10.1016/j.jaip. 2016.01.015 48. Li Y, Wu R, Tian Y, Bao T, Tian Z. The correlation of serum eosinophil cationic protein level with eosinophil count, and total Ige level in Korean adult allergic rhinitis patients. Asian Pac J Allergy Immunol. (2016) 34:33–7. 49. A G, Rasheed Z, Salama RH, Salem T, Ahmed AA, Zedan K, et al. Filaggrin, major basic protein and leukotriene B4: biomarkers for adult patients of bronchial asthma, atopic dermatitis and allergic rhinitis. Intract Rare Dis Res. (2018) 7:264–70. doi: 10.5582/irdr.2018.01111 50. Kim JH, Yoon MG, Seo DH, Kim BS, Ban GY, Ye YM, et al. Detection of allergen specific antibodies from nasal secretion of allergic rhinitis patients. Allergy Asthma Immunol Res. (2016) 8:329–37. doi: 10.4168/aair.2016.8.4.329 51. A G, Rasheed Z, Salama RH, Salem T, Ahmed AA, Zedan K, et al. Filaggrin, major basic protein and leukotriene B4: biomarkers for adult patients of bronchial asthma, atopic dermatitis and allergic rhinitis. Intract Rare Dis Res. (2018) 7:264–70. doi: 10.5582/irdr.2018.01111 52. Hoffmann HJ, Santos AF, Mayorga C, Nopp A, Eberlein B, Ferrer M, et al. The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease. Allergy. (2015) 70:1393–405. doi: 10.1111/all.12698 53. 4Campo P, Eguiluz-Gracia I, Bogas G, Salas M, Plaza Seron C, Perez N, et al. Local allergic rhinitis: implications for management. Clin Exp Allergy. (2019) 49:6–16. doi: 10.1111/cea.13192 54. Aggarwal R, Ringold S, Khanna D, Neogi T, Johnson SR, Miller A, et al. Distinctions between diagnostic and classification criteria? Arthritis Care Res (Hoboken). (2015) 67:891–7. doi: 10.1002/acr.22583 55. Nur Husna SM, Shukri N, Tan HTT, Mohd Ashari NS, Wong KK. Higher wheal sizes of dermatophagoides farinae sensitization exhibit severe nasal symptoms in allergic rhinitis patients. Front Med. (2022) 9:461. doi: 10.3389/ fmed.2022.843432 56. van der Valk JP, Gerth van Wijk R, Hoorn E, Groenendijk L, Groenendijk IM, de Jong NW. Measurement and interpretation of skin prick test results. Clin Transl Allergy. (2015) 6:8. doi: 10.1186/s13601-016-0092-0 57. Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the world health organization, GA(2)LEN and AllerGen). Allergy. (2008) 63(Suppl. 86):S8–160. doi: 10.1111/j.1398-9995.2007.01620.x 58. Wheatley LM, Togias A. Clinical practice. Allergic rhinitis. N Engl J Med. (2015) 372:456–63. doi: 10.1056/NEJMcp1412282 59. Brozek JL, Bousquet J, Agache I, Agarwal A, Bachert C, Bosnic-Anticevich S, et al. Allergic rhinitis and its impact on asthma (ARIA) guidelines-2016 revision. J Allergy Clin Immunol. (2017) 140:950–8. doi: 10.1016/j.jaci.2017. 03.050 60. Justiz Vaillant AA, Zito PM. Hypersensitivity Reactions, Immediate. Treasure Island, FL: Statpearls (2018), He JS, Narayanan S, Subramaniam S, Ho WQ, Lafaille JJ, Curotto de Lafaille MA. Biology of Ige production: Ige cell differentiation and the memory of Ige responses. Curr Top Microbiol Immunol. (2015) 388:1–19. doi: 10.1007/978- 3-319-13725-4_1 61. Moon TC, Befus AD, Kulka M. Mast cell mediators: their differential release and the secretory pathways involved. Front Immunol. (2014) 5:569. doi: 10. 3389/fimmu.2014.00569 63. Finkelman FD, Khodoun MV, Strait R. Human Ige-independent systemic anaphylaxis. J Allergy Clin Immunol. (2016) 137:1674–80 62. Sin B, Togias A. Pathophysiology of allergic and nonallergic rhinitis. Proc Am Thorac Soc. (2011) 8:106–14. doi: 10.1513/pats.201008-057RN 63. Sin B, Togias A. Pathophysiology of allergic and nonallergic rhinitis. Proc Am Thorac Soc. (2011) 8:106–14. doi: 10.1513/pats.201008-057RN 64. Pawankar R, Yamagishi S, Yagi T. Revisiting the roles of mast cells in allergic rhinitis and its relation to local Ige synthesis. Am J Rhinol. (2000) 14:309–17. doi: 10.2500/105065800781329582 65. Pawankar R, Yamagishi S, Yagi T. Revisiting the roles of mast cells in allergic rhinitis and its relation to local Ige synthesis. Am J Rhinol. (2000) 14:309–17. doi: 10.2500/105065800781329582 66. Plewako H, Holmberg K, Oancea I, Gotlib T, Samolinski B, Rak S. A followup study of immunotherapy-treated birch-allergic patients: effect on the expression of chemokines in the nasal mucosa. Clin Exp Allergy. (2008) 38:1124–31. doi: 10.1111/j.1365-2222.2008.03005.x 67. Aalberse RC. Structural biology of allergens. J Allergy Clin Immunol. (2000) 106:228–38. doi: 10.1067/mai.2000.108434 68. Hosseini S, Shoormasti RS, Akramian R, Movahedi M, Gharagozlou M, Foroughi N, et al. Skin prick test reactivity to common aero and food allergens among children with allergy. Iran J Med Sci. (2014) 39:29–35 69. Thomsen SF. Epidemiology and natural history of atopic diseases. Eur Clin Respir J. (2015) 2:24642. doi: 10.3402/ecrj.v2.24642 70. Lambrecht BN, Hammad H. The immunology of the allergy epidemic and the hygiene hypothesis. Nat Immunol. (2017) 18:1076–83. doi: 10.1038/ni.3829 71. Ma T, Wang X, Zhuang Y, Shi H, Ning H, Lan T, et al. Prevalence and risk factors for al-lergic rhinitis in adults and children living in different grassland regions of Inner Mongolia. Allergy. (2020) 75:234–9. doi: 10.1111/all.13941 72. Wang JY, Kishore U, Lim BL, Strong P, Reid KB. Interaction of human lung surfactant proteins A and D with mite (Dermatophagoides pteronyssinus) allergens. Clin Exp Immunol. (1996) 106:367–73. doi: 10.1046/j.1365-2249. 1996.d01-838.x 73. Madan T, Kishore U, Singh M, Strong P, Clark H, Hussain EM, et al. Surfactant proteins A and D protect mice against pulmonary hypersensitivity induced by Aspergillus fumigatus antigens and allergens. J Clin Invest. (2001) 107:467–75. doi: 10.1172/JCI10124 74. Астафьева Н.Г., Баранов А.А., Вишнева Е.А., Дайхес Н.А., Жестков А.В., Ильина Н.И. и др. Аллергический ринит: клинические рекомендации. М.; 2016. 84 с. Режим доступа: https://raaci.ru/dat/pdf/allergic_rhinitis-project.pdf. 75. Белан Э.Б., Садчикова Т.Л. Аллергический ринит: современные подходы к диагностике и лечению. Лекарственный вестник. 2017;(3):3–10. Режим доступа: https://elibrary.ru/item.asp?id=30095062 76. Гуртовая М.Н., Гребнева Н.Н., Прокопьев Н.Я. Аллергический ринит и бронхиальная астма: частота встречаемости, причины возникновения, клиника и лечение (обзор иностранной литературы). Молодой ученый. 2014;(2):318–326. Режим доступа: https://moluch.ru/archive/61/9005/. 77. Овчаренко С.И., Опаленова В.А. Аллергический ринит и бронхиальная астма: оценка эффективности Лордестина. Фарматека. 2012;(15):84–88. Режим доступа: https://pharmateca.ru/ru/archive/article/8594. 78. Пальчун В.Т., Гусева А.Л., Левина Ю.В., Дербенева М.Л. Фармакотерапия аллергического ринита. Медицинский совет. 2020;(16):122–127. doi: 10.21518/2079-701X-2020-16-122-127. 79. Рязанцев С.В., Павлова С.С. Отражение современных концепции терапии при лечении аллергических заболеваний носа и околоносовых пазух. Медицинский совет. 2020;(6):78–84. doi: 10.21518/2079-701X2020-6-78-84. 80. Шиленкова В.В., Лопатин А.С. Аллергический ринит и качество жизни. Российская ринология. 2019; 27(4):215–223. 81. Bernstein D.I., Schwartz G., Bernstein J.A. Allergic Rhinitis: Mechanisms and Treatment. Immunol Allergy Clin North Am. 2016;36(2):261–278. doi: 10.1016/j.iac.2015.12.004. 82. Brożek J.L., Bousquet J., Agache I., Agarwal A., Bachert C., BosnicAnticevich S. et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines – 2016 revision. J Allergy Clin Immunol. 2017;140(4):950–958. 83. Rondón C., Campo P., Togias A., Fokkens W.J., Durham S.R., Powe D.G., Mullol J., Blanca M. Local allergic rhinitis: concept, pathophysiology, and management. J Allergy Clin Immunol. 2012;129(6):1460–1467. 84. Nevis1 I.F., Binkley K., Kabali C. Diagnostic accuracy of skin-prick testing for allergic rhinitis: a systematic review and meta-analysis. Allergy Asthma Clin Immunol. 2016;12:20.