Biomeditsina va amaliyot jurnali, 2023 №1

Тема статьи

CLINICAL SIGNIFICANCE OF CHANGES IN THE RECEPTOR STATUS IN TUMORS OF THE ACCESSORY LOBE OF THE MAMMARY GLAND (168-173)

Авторы

Alimkhodzhaeva T. Lola, Nishanov A. Doniyor, Bozorova M. Lutfiyahon, Norbekova Kh. Munira

Учреждение

Tashkent Medical Academy

Аннотация

In recent years, along with breast cancer, there has also been an increase in accessory breast cancer (AMBC). According to most experts, the prognosis of ADBC is determined by its early diagnosis, which requires careful screening among women at high risk, which include, first of all, patients with precancerous lesions of the breast. In recent years, the IHC method has become widely used by researchers in the study of intraepithelial neoplasia of the mammary gland and its lobes for early diagnosis and prognosis. However, in most published studies using this method, a limited number of markers does not allow to fully clarify the biological profile of the diseases under study, there are no data on the prognostic significance of these types of neoplasia, and a comprehensive diagnostic algorithm combining morphological and IHC criteria has not been defined.

Ключевые слова

Breast cancer, cancer of the accessory lobe of the breast, immunohistochemistry, dysplasia, invasion.

Литературы

ессмертный Д.В. Дифференциальные критерии при клинико-морфологических параллелях прогноза рака предстательной железы: автореф. дис…. Канд. мед. наук.- Ростов/Дону, 2012.- 24 с. 2. Бусько Екатерина Александровна Мультипараметрическое ультразвуковое исследование в ранней диагностике и мониторинге лечения рака молочной железы: автореф. дис… докт. мед. наук.- СПб, 2021.- 43 с. 3. Ковылина М.В. Клиническая и морфологическая характеристика раковых и предраковых заболеваний простаты: автореф. дис… канд. мед. наук.-М., 2007.- 25с 4. Полетаева С.В. Морфологическая оценка результатов лечения рака предстательной железы: Автореф. дис… канд. мед. наук.-Саратов, 2015.- 25 с. 5. Беркут М.В. Предиктивная роль патоморфологического и молекулярного типирования при радикальном лечении больных раком предстательной железы высокого риска. Автореф. дис… канд. мед. наук.- 2020.- 26 с. 6. Охриц, Валерия Евгеньевна Диагностические и прогностические факторы рака предстательной железы: Автореф. дис… канд. мед,наук.- 2012.- 24 с. 7. Shavkatovna, S. S., Maxammatkulovich, R. N., & qizi, S. N. A. (2022). Breast Pathology in Adolescent Girls. Central Asian Journal of Medical and Natural Science, 3(3), 66-71. https://doi.org/10.17605/OSF.IO/MVD63 8. Kristiansen G. Markers of clinical utility in the differential diagnosis and prognosis of prostate cancer. //Mod Pathol.- 2018 Jan;31(S1):S143-155. 9. Sanguedolce F, Cormio A, Musci G, Troiano F, Carrieri G, Bufo P, Cormio L. Typing the atypical: Diagnostic issues and predictive markers in suspicious prostate lesions. //Crit Rev Clin Lab Sci. 2017 Aug;54(5):309-325. 10. Zhao F, Olkhov-Mitsel E, Kamdar S, Jeyapala R. A urine-based DNA methylation assay, ProCUrE, to identify clinically significant prostate cancer. //Clin Epigenetics. 2018 Nov 23;10(1):147. 11. Moreira-Barbosa C, Barros-Silva D, Comparing diagnostic and prognostic performance of twogene promoter methylation panels in tissue biopsies and urines of prostate cancer patients. //Clin Epigenetics. 2018 Oct 29;10(1):132. 12. Van Neste L, Partin AW, Stewart GD, Epstein JI, Harrison DJ, Van Criekinge W. Risk score predicts high-grade prostate cancer in DNA-methylation positive, histopathologically negative biopsies. //Prostate. 2016 Sep;76(12):1078-87. 13. Sánchez BE, Aguayo A, Martínez B, Rodríguez F. Using Genetic and Epigenetic Markers to Improve Differential Diagnosis of Prostate Cancer and Benign Prostatic Hyperplasia by Noninvasive Methods in Mexican Patients. //Clin Genitourin Cancer. 2018 Aug;16(4):e867- e877. 14. Rizaev J. A., Maeda H., Khramova N. V. Plastic surgery for the defects in maxillofacial region after surgical resection of benign tumors //Annals of Cancer Research and Therapy. – 2019. – Т. 27. – №. 1. – С. 22-23. 15. Rizaev Jasur, Norbutayev Alisher, Murtazayev Alisher. Modern methods for detecting oral cavity defects in hemoblastosis, detecting the degree of damage and prediction of the clinical current. Journal of Biomedicine and Practice. 2021, vol. 6, issue 5, pp. 45-51 􀁔􀁛􀁡􀁟􀁘􀁗􀁛􀁩􀁛􀁠􀁓􀀃􀁕􀁓􀀃􀁓􀁟􀁓􀁞􀁛􀇜􀁥􀀃􀁙􀁦􀁣􀁠􀁓􀁞􀁛􀀃􀀃􀂬􀀃􀀃􀁙􀁦􀁣􀁠􀁓􀁞􀀃􀁔􀁛􀁡􀁟􀁘􀁗􀁛􀁩􀁛􀁠􀁮􀀃􀁛􀀃􀁢􀁣􀁓􀁝􀁥􀁛􀁝􀁛􀀃􀀃􀂬􀀃􀀃􀀉􀀎􀀔􀀑􀀍􀉮􀀋􀀃􀀎􀀅􀀃􀉸􀀈􀀎􀀌􀀄􀉖􀀈􀉹􀀈􀀍􀀄􀀃􀉮􀀍􀉖􀀃􀀏􀀑􀉮􀉹􀀓􀀈􀉹􀀄 №1 | 2023 173 16. Shakhanova Shakhnoza, Rakhimov Nodir, Zaripova Parvina. Breast tumors in adolescent girls // Journal of Biomedicine and Practice. 2022, vol. 7, issue 3, pp.266-273 17. Lutfillo Yorov, Mirjalol Djuraev, Nodir Raximov, Shakhnoza Shakhanova. Evaluation of the state of the immune status in patients with breast cancer with the determination of the effectiveness of neoadjuvant polychemotherapy. Journal of Biomedicine and Practice. 2022, vol. 7, issue 5, pp.211-216