Kardiorespirator tadqiqotlar jurnali №1 2022.pdf
Subject of the article
SARS-COV-2 KORONAVIRUS BO'LGAN BEMORLARNI DAVOLASHDA FENOFIBRATNING O'RNI (9-12)
Authors
I.R. Agababyan, F.N.Juraqulov, Ismoilova Y.A.
Institution
Samarqand davlat tibbiyot universiteti
Abstract
Hozirgi pandemiya va o‘tkir nafas olish sindromi (SARS-CoV-2) butun dunyo bo‘ylab o‘limga olib keldi. Bugungi kunda vafot etganlar soni 4,55 milliondan oshdi. SARS-CoV-2 infeksiyasini qo‘shimcha samarali davolash uchun dori-darmonlarni aniqlash uchun hujayra asosiy virus kirish retseptorlari bo‘lgan angiotenzin aylantiruvchi ferment 2 (ACE2) dimerizatsiyasini o‘lchash uchun ekran yaratildi. Bu ekran fenofibratning faol metaboliti bo‘lgan fenofibrik kislotani aniqladi. Fenofibrin kislota, shunigdek, virusli oqsilning retseptorlari bilan bog’lanish sohasini (RBD) beqarorlashtirdi va ferment bilan bog’liq immunoferment taxlilida RBD ning ACE2 ga bog’lanishi aniqlandi. Fenofibrat va fenofibrin kislota ikkita mustaqil laboratoriya tomonidan sinovdan o‘tkazilgan. Ikkala holatda ham, preparatning klinik dozalarda konsentratsiyasida fenofibrat va fenofibrin kislota virusli infeksiyani 70% gacha kamaytirdi. Keng klinik anamnez va nisbatan yaxshi xavsizlik profiliga ega keng bo‘lgan holda, ushbu tadqiqot fenofibratni gipertenziya va tana massasi indeksi yuqori bo‘lgan bemorlarda SARS-CoV-2 infeksiyasini davolash uchun klinik baholashni talab qiladigan potensial terapevtik vosita sifatida aniqlaydi.
Key words
fenofibrat, SARS-CoV-2, ACE2, retseptorlarni bog’lovchi domen (RBD), IFA.
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