Doktor axborotnomasi 2024, №3 (115)

Subject of the article

SUYAK TO‘QIMALARINING STRUKTURAVIY VA FUNKTSIONAL HOLATINING XUSUSIYATLARI (167-172)

Authors

O. V. Kim, Sh. A. Yusupov, S. T. Musoyev

Institution

Samarqand davlat tibbiyot universiteti, Samarqand, O‘zbekiston

Abstract

Ushbu maqolada suyak to‘qimasining strukturasi, suyak morfogen oqsillari, kollagen oqsillarning metabolizmi, ularning organizmda tarqalishi hamda suyak to‘qimasi hosil bo‘lish intensivligi va rezorbsiyasini baholash uchun marker sifatida qo‘llanilish imkoniyatlari muhokama qilinadi.

Key words

suyak to‘qimasi, kollagen, suyak markerlari, modellashtirish, qayta qurish.

Literature

1. Ansoriy, N. A. Fermentativ bo‘lmagan oqsil glikatsiyasi: diabetdan saratongacha / N. A. Ansoriy, Z. Rashid / / biotibbiyot kimyosi. – 2010. - Jild 56. – №2. 168 -178-b. 2. Biokimyo: darslik / Ed. M.: Geotar-MED, 2003 yil. 784b. 3. Boychuk, N. V. Gistologiya, embriologiya, sitologiya: darslik / subreddit. E. G. Ulumbekova, Y. A. Chelisheva. Moskva: Geotar-Media, 2016. 928b. 4. Biriktiruvchi to‘qima matritsasining minerallashgan to‘qimalarining biokimyosi: o‘quv qo‘llanma / N. V. Savinova [va boshqalar]; Ed. Ijevsk, 2012 yil. 110b. 5. Mayanskiy, D. N. Klinik patologiya bo‘yicha ma’ruzalar / shifokorlar uchun qo‘llanma. M.: Geotar-Media, 2007. 464 b. 6. Omelyanenko, N. P. Suyak to‘qimasi. Uning asosiy tarkibiy qismlarining tarkibiy va funktsional xususiyatlari // nazariy va klinik osteoartritning dolzarb muammolari. Moskva, 2005 yil. 37-81 betlar. 7. Pikalyuk, V. S. Suyak to‘qimalarining biologiyasi va funktsiyasi haqidagi zamonaviy g‘oyalar / V. S. Pikalyuk, S. O. Mostova // Tavriya tibbiy-biologik xabarnomasi. – 2006. - Jild 9. – №3. 186-189-b. 8. Severin, E. S. Biologik kimyo / E. S. Severin, T. L. Aleynikova, E. V. Osipov, S. A. Silayeva. - M.: "Tibbiy axbo rot agentligi" MCHJ, 2008 yil. 364b. 9. Smirnov A. V., Rumyantsev A.Sh. "Suyak to‘qimalarining tuzilishi va funktsiyasi normal va patologiyada" xabar I nefrologiya. 2014. 18-jild. №6. 9-10-b. 10. Suyak to‘qimalarining mineral matritsasini tashkil etish darajasi va ularning shakllanish parametrlarini aniqlaydi gan mexanizmlar / A. S. Avrunin [va boshqalar] // morfologiya. – 2005. - Jild 127, № 2. 78-82 betlar. 11. Toroptsova, N. V. suyak metabolizmining biokimyoviy markerlari yordamida terapiya samaradorligini prognoz qilish / N. V. Toroptsova, O. A. Nikitinskaya / / Ukraina revmatologiya jurnali. – 2011. - Jild 3. – №45. 35-38-b. 12. Atkinson, M.A. The Pathogenesis and Natural History of Type 1 Diabetes / M.A. Atkinson // Cold Spring Harb Perspect Med. – 2012. – Vol.2. – №11. 13. Boudko, S.P. Autosomal Recessive Osteogenesis Imperfecta: A Puzzle for Bone Formation, Structure and Func tion / S.P. Boudko, E.N. Pokidysheva, H.P. Bächinger // Curr Genet Med Rep. – 2013. – Vol.1. – P.239-246. 14. Butolin E. G. et al. Role of biomarkers of organic matrix of bone tissue in chronic hematogenous osteomyelitis in children. //European journal of molecular medicine. – 2022. – Т. 2. – №. 5. 15. Chung, H.J. Collagen Fibril Formation / H.J. Chung, A. Steplewski, K.Y. Chung [et al.] // J. Biol. Chem. – 2008. – Vol.283. – №38. – P.25879-25886. 16. Chung, H.J. Collagen Fibril Formation / H.J. Chung, A. Steplewski, K.Y. Chung [et al.] // J. Biol. Chem. – 2008. – Vol.283. – №38. – P.25879-25886. 17. Crockett, J.C. Bone remodelling at a glance / J.C. Crockett, M.J. Rogers, F.P. Coxon [et al.] // J. Cell. Sci. – 2011. – Vol.124. – №7. – P.991-998. 18. Howes, J. The Recognition of Collagen and Triple-helical Toolkit Peptides by MMP-13 / J. Howes, D. Bihan, D.A. Slatter [et al.] // J. Biol. Chem. – 2014. – Vol.289. – №35. – P.24091-24101. 19. Kim O. V., Fayzullayeva X. B. Possibilities of clinical application of organic bone matrix in chronic hematog enous osteomyelitis in children //SCHOLAR. – 2023. – Т. 1. – №. 29. – P. 164-172. 20. Nakanishi, K. Combination of HLA-A24, -DQA1*03, and -DR9 Contributes to Acute-Onset and Early Complete β-Cell Destruction in Type 1 Diabetes: Longitudinal Study of Residual β-Cell Function / K. Nakanishi, H. Inoko // Diabetes. – 2006. – Vol.55. – №6. – P.1862-1868. 21. Panwar, P. Effects of Cysteine Proteases on the Structural and Mechanical Properties of Collagen Fibers / P. Panwar, X. Du, V. Sharma [et al.] // J. Biol. Chem. – 2013. – Vol.288. – №8. – P.5940-5950. 22. Parisuthiman, D. Biglycan Modulates Osteoblast Differentiation and Matrix Mineralization / D. Parisuthiman, Y. Mochida, W. R. Duarte [et al.] // J. Bone Miner. Res. – 2005. – Vol.20. – №10. – P.1878-1886. 23. Sarkar, S.K. Single-molecule Tracking of Collagenase on Native Type I Collagen Fibrils Reveals Degradation Mechanism / S.K. Sarkar, B. Marmer, G. Goldberg [et al.] // Curr Biol. – 2012. – Vol.22. – №12. – P.1047-1056. 24. Schett, G. Cells of the synovium in rheumatoid arthritis. Osteoclasts / G. Schett // Arthritis Res. Ther. – 2007. – Vol.9.