Doktor axborotnomasi 2024, №3 (115)

Subject of the article

FEATURES OF THE IMMUNE SYSTEM IN ENDOMETRIAL HYPERPLASIA IN THE PERIMENOPAUSAL PERIOD (63-68)

Authors

N. О. Nurkhanova

Institution

Bukhara state medical institute, Bukhara, Uzbekistan

Abstract

This article discusses the immunological features of the development of endometrial hyperplasia in women in the perimenopausal period. Markers of proliferation and apoptosis and pro-inflammatory cytokines in the blood serum were examined in women. They were divided into two groups (group 1 - HE, group 2 - recurrent HE turning to PHE), and it was revealed that in both groups of women, immunological changes were unidirectional, but more pronounced immunological changes were observed in the second group. Common properties for the studied groups were a de crease in the level of CD25+ and CD95+ cells and a significant increase in the level of IL-1β, IL-6, TNFα and a de crease in IL-2. Based on the results obtained, it cannot be unequivocally stated that the detected changes are directly related to the local processes of the reproductive organs in women with GE and possibly reflect the premorbid back ground of the patients. All this dictates the need for additional tests to study local immunity.

Key words

GE, PGE, CD25+, CD95+, IL-1β, IL-2, IL6, TNFα.

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