Биология ва тиббиёт муаммолари 2024 №3 (154)
Subject of the article
THE STATE OF THE HEMOSTASIS SYSTEM IN YOUNG CHILDREN WITH ACUTE PNEUMONIA LIVING IN AN ECOLOGICALLY UNFAVORABLE ZONE (KHOREZM REGION) (335-338)
Authors
Yusupova Umidajon Ulugbekovna
Institution
Urgench branch of the Tashkent Medical Academy, Republic of Uzbekistan. Urgench
Abstract
Acute community-acquired pneumonia (ACP) in children remains one of the most severe diseases leading to high mortality (up to 16% or more) among patients under the age of 5 years. Information on the relationship between cytokine status and hemostasis in children with pneumonia, taking into account the influence of unfavorable environmental conditions, is practically absent. In this regard, the next stage of our work was to study the correlation between hemo-stasis indicators and serum cytokine levels in the blood of children with acute community-acquired pneumonia in children living in Khorezm, the indicators of the coagulation link of the hemostasis system showed a high thrombotic preparedness for DIC. The imbalance of hemostasis indicators dictates the expediency of correcting and preventing these conditions for more successful control over the process and timely complete treatment.
Key words
community-acquired pneumonia, hemostasis, ecology, children.
Literature
1.Mamatkulova D.Kh., Bobomuratov T.A. Clinical and pathogenetic significance of changes in hemostasis disorders and ways of their correction in chronic pneumonia in children. Medical Sciences. 2004; 2:29-30. 2. Dorokhov N.A. Diagnostic possibilities for determining D-dimers from soluble fibrin-monomer complexes in pediatric practice // Vestnik RSMU - 2012. - Special issue. 1. -S. 421. 3. Bakradze M.D., Gadlia D.D., Rogova O.A., Khokhlova T.A., Tatochenko V.K. On the problems of diagnosis and treatment of pneumonia in children // Pediatric pharmacology.-2015.- Volume 12.- No. 3.-C.354-359. 4.Dudina K.R., Kutateladze M.M., Znoiko O.O., et al. Clinical significance of markers of acute inflammation in infectious pathology // Kazan Medical Journal.- 2014.- Volume 95.-№6.-S.909-915. 5.WHO Newsletter. November 2016 mediainquiries@who.int. 6.Dobrykh V.A. Influence of environmental factors on the localization of unilateral community-acquired pneumonia // Pulmonology. –2018. - No. 1. - P.64-67. 7.Busoedov A.V. Effect of a synthetic peptide in burns in rats on hemostasis in a microcoagulation test. FGBOU VO "Chita State Medical Academy" 2017.S.14-17. 8. Geppe N.A., Rozinova N.N., Volkov I.K., Mizernitsky Yu.L. Working classification of the main clinical forms of bronchopulmonary diseases in children // Russian Respiratory Society. M., 2019. 18 p. 9. Diagnosis of community-acquired pneumonia in children and rationale for antibiotic therapy: scientific publication / F. M. Shamsiev [et al.] // Journal of Theoretical and Clinical Medicine. - Tashkent, 2018. - N6. - C. 31-34. 10.Donos A.A., Garaeva S.N. The profile of free amino acids in the blood serum as an indicator of the immune status of frequently ill children and children with acute pneumonia// Eurasian Union of Scientists (ESU) .- medical sciences.-1 (21), 2015.-p.60-63. 11.Kochegarova E.Yu. Forecasting the course of community-acquired pneumonia / E.Yu. Kochegarova, V.P. Kolosov // Bulletin of Physiology and Pathology of Respiration. - 2020- Issue 37. - S. 42-46. 12. Movlonova Sh. S. Factors influencing the development of nosocomial pneumonia in children according to retrospective studies: VIII Congress of Pediatricians of Uzbekistan "Providing medical care to children at the stage of reforming the healthcare system of the Republic of Uzbekistan" (Tashkent, October 15-16, 2019) / Sh. S. Movlonova, F. M. Shamsiev, M. M. Khaidarova // Pediatrics. - Tashkent, 2019. - N3. - C. 199-204. 13. Bobomuratov T.A. Study of the hemostasis system and evaluation of the effectiveness of lymphotropic anticoagulant therapy in young children with acute pneumonia. Lymphology. Andijan. 2000; 1-2:9-13. 14. Abdullaev R.B., Duschanov Sh.B., Matkarimova D.S., Musaev M.R., Khamidova G.S., Abdullaev I.R. Aral crisis: problems of ecological culture and health. - Urgench, 2012. - 116 p. 15. Geppe N.A., Rozinova N.N., Volkov I.K., Mizernitsky Yu.L. Working classification of the main clinical forms of bronchopulmonary diseases in children // Russian Respiratory Society. M., 2019. 18 p.