Биология ва тиббиёт муаммолари 2024 №2 (152)
Subject of the article
LABORATORY INDICATORS IN RATS EXPOSED TO ISOLATED AND COMBINED EXPOSURE TO LEAD AND CHROME (276-281)
Authors
Kim Tat`yana Aleksandrovna, Mavlyanova Zilola Farkhadovna
Institution
1 - Asfendiyarov Kazakh National Medical University, Republic of Kazakhstan, Almaty; 2 - Samarkand State Medical University, Republic of Uzbekistan, Samarkand
Abstract
Knowledge of the nature of disorders of the endocrine apparatus of the pancreas as a result of exposure to heavy metals and the development of diabetes mellitus under these conditions will contribute to a deeper understanding of the pathogenesis of this disease and, consequently, the creation of rational methods of prevention. In this connection, the article presents some aspects of the pathogenesis of the damaging effects of lead and chromium compounds on the en-docrine function of the pancreas of rats. To conduct the experiment, depending on the substance that caused the intoxication, 4 groups of animals were formed: 1 group – “lead” (n=33); Group 2 – “chrome” (n=40); Group 3 – “lead+chromium” (n=108); Group 4 - “ intact ” (n=47). It has been shown that combined exposure to metals leads to more pronounced activation of free radical oxidation processes, as a result of which excess lipid peroxidation is induced, which in turn leads to greater damage to pancreatic β- cells and the development of hypoinsulinemia in these animals, compared with isolated exposure metals, where hypoinsulinemia was not observed. The presence of mortality and a greater decrease in body weight in the “lead + chromium” group, in contrast to the comparison groups, also indicate a more pronounced toxic effect of the combination of metals on the body compared to their isolated effect.
Key words
lead, chromium, pancreas, rats, lipid peroxidation, antioxidant system.
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