Doktor axborotnomasi 2024, №1 (113)

Subject of the article

RELATIONSHIP OF MORTALITY DEPENDING ON TREATMENT TACTICS IN ADOLESCENTS AND ADULTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA (5-7)

Authors

N. B. Abdukadirova, N. Y. Turayeva, Sh. T. Xayatova

Institution

Samarkand state medical university, Samarkand, Uzbekistan

Abstract

This article reviews a survey that included 296 diagnosed cases of acute lymphoblastic leukemia (ALL) over the age of 12 years. The diagnosis of ALL was made on the basis of bone marrow aspiration, biopsy, flow cytometry, and cytogenetics. In this study, complete remission was observed in 90.9% of cases. The treatment-related mortality rate was 15.3%.

Key words

acute lymphoblastic leukemia (ALL), treatment -related mortality, remission induction, Philadelphia chromosome.

Literature

1. Abdukadirova N. B., Rabbimova D. T., Khayatova Z. B. The role of connective tissue dysplasia in the develop-ment of pathology of various body systems //Journal of Siberian Medical Sciences. – 2020. – №. 3. – С. 126-135. 2. Abdukadirova N. B., Ibatova S. M. Features of the course of serous meningitis of enterovirus etiology in chil-dren //Евразийский журнал медицинских и естественных наук. – 2023. – Т. 3. – №. 4. – С. 15-20. 3. Abdukadirova N. B., Telmanovna X. S. Options clinical manifestations of giardiasis in children //Eurasian Re-search Bulletin. – 2023. – Т. 17. – С. 167-170. 4. Abdukadirova N. B., Telmanovna X. S. Assessment of the Level of Immunoglobulins in the Blood Serum in Young Children Depending on the Type of Feeding //Eurasian Research Bulletin. – 2023. – Т. 17. – С. 164-166. 5. Abdukadirova N.B., Khayatova S.T., and Shadieva Kh.N. "Clinical and Laboratory Features of the Course of Se-rous Meningitis of Enterovirus Etiology in Children." The Peerian Journal 16 (2023): 19-24. 6. Abdukadirova N. B., Telmanovna X. S. Assessment of the Level of Immunoglobulins in the Blood Serum in Young Children Depending on the Type of Feeding //Eurasian Research Bulletin. – 2023. – Т. 17. – С. 164-166. 7. Abdukadirova N. B., Telmanovna X. S. Options clinical manifestations of giardiasis in children //Eurasian Re-search Bulletin. – 2023. – Т. 17. – С. 167-170. 8. Ibatova S. M. et al. Gas-chromatographic appraisal of application of apricot oil and aevit in complex therapy of vitamin d-deficiency rickets in children //Theoretical & Applied Science. – 2019. – №. 4. – С. 333-336. 9. Ibatova S. M., Mamatkulova F. K., Abdukadirova N. B. Characteristics of the clinical course of acute panceratitis in children //EPRA International Journal of Multidisciplinary Research (IJMR). – 2023. – Т. 9. – №. 3. – С. 271-273. 10. Ibatova S. M. et al. Risk factors for development of broncho-ostructive syndrome in children //International Jour-nal of Current Research and Review. – 2020. – Т. 12. – №. 23. – С. 3-6. 11. Inclan-Alarcon SI, Riviello-Goya S, Teran-De-la-Sancha K, Fierro-Angulo OM, Acosta-Medina AA, Demichelis-Gomez R, Burlon C. Induction-related mortality in adolescents and young adults with acute lymphoblastic leuke-mia in a resource-limited setting: do treatment-related complications create more impact than disease biology? Blood Res. 2022 Mar 31;57(1):29-33 12. Larson RA, Dodge RK, Burns CP, et al. A five-drug induction regime with intensive consolidation for adult acute lymphoblastic leukemia: Cancer and leukemia group B study. 13. Mohammed DJ, Jalal SD, Yassin AK, Mohammed AI, Al-Allawi NA. The Outcome of Acute Lymphoblastic Leu-kemia in 109 Adult Iraqi Patients. Indian J Hematol Blood Transfuse. 2021 Apr;37(2):264-70. 14. Paul S, et al. Adult Acute Lymphoblastic Leukemia. Mayo Clin. Proc. 2016; 91:1645–66. 15. Shadieva Kh.N., Bozorova N.S., Abdukadirova N.B. Heart Damage and Arrhythmias in Children After Corona-virus Infection: Early and Remote Observations //Eurasian Research Bulletin. – 2023. – Т. 18. – С. 61-64.