Биология ва тиббиёт муаммолари 2024 №1 (151)

Subject of the article

GUT MICROBIOTA IN PATIENTS WITH AUTOIMMUNE DISEASES (388-392)

Authors

Ziyadullaev Shukhrat Hudayberdiyevich, Payzullaeva Umida Furkat kizi

Institution

Samarkand State Medical University, Republic of Uzbekistan, Samarkand

Abstract

Autoimmune diseases are diseases associated with disruption of the functioning of the human immune system, which begins to recognize its own tissues as foreign and damage them. In this case, not only a specific system can be affected, but also the entire system or even the entire human body is affected. In this regard, such diseases are also called systemic. Until today, scientists have not fully identified the reason for the negative reaction of the human immune system to its own cells or tissues. Most of these diseases are chronic.Understanding of the processes occurring within the body has changed significantly due to modern technology, which has allowed us to reveal the close relationship of the intestine with the nervous, endocrine, and immune systems of the human body. It is believed that the majority of chronic diseases of multifactorial nature are based on changes in the species diversity of the intestinal microbiota, which lead to irreversible breakdowns in the homeostasis of the macroorganism. Dysfunction associated with disturbances in the qualitative and quantitative composition of the gut microbiota alters metabolic activity and promotes the development of chronic inflammation.

Key words

intestinal (gut) microbiota, autoimmune diseases, microbiocenoses.

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