Biomeditsina va amaliyot jurnali, 2022 №2
Subject of the article
STUDY OF THE ANTITUMOR ACTIVITY OF THE DRUG COLHAMETIN (K-2) ON 2 SOLID TUMORS OF MICE IN COMPARISON WITH A NUMBER OF CYTOSTATICS (230-235)
Authors
Yuldashev Zhovlon, Abdukhalilov Majid, Rakhimov Nodir, Enikeeva Zulfiya, Ibragimov Shavkat
Institution
Samarkand State Medical Institute Doctor of Medical Sciences Republican Cancer Research Center
Abstract
ABSTRACT The aim of the study was to study the antitumor activity of the new antitumor drug "colhametin" (K-2) on 2 tumor strains. Material and research methods. The study of antitumor activity was performed on 42 outbred and 34 strain mice with transplanted tumors Ehrlich's solid tumor (EST) and AKATOL, which were injected with drugs on the 4th day after tumor inoculation 10 times. The results were evaluated according to standard criteria: tumor growth inhibition (TGI), body weight and spleen weight of animals. Differences were considered significant at p<0.05. Results. The study of the activity of the new developed antitumor drug colhametin (K-2) revealed that the drug inhibits the growth of tumors: AKATOL by 94/91%, Erlikhan's solid tumor by 92/78%, more than 50% more active than colhamin and 9- 20% more active than taxol and etoposide. Conclusions. The studied substance can be submitted for clinical trials, as it meets the requirements for a promising anticancer drug, in addition, its activity is higher than the effect of drugs used for comparison.
Key words
Key words: antitumor activity, new drug K-2, Ehrlich solid tumor AKATOL, comparator drugs, side effect.
Literature
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