Biomeditsina va amaliyot jurnali, 2022 №2
Subject of the article
THE DEGREE OF CYTOLOGICAL DAMAGE OF THE EPITHELIUM OF THE MUCOSA OF THE BEACH WITH COVID-19 (156-163)
Authors
ZEYNITDINOVA Ziyoda Askarovna RIZAEV Jasur Alimdjanovich ORIPOV Firdavs Suratovich
Institution
Tashkent State Medical Institute Samarkand State Medical Institute
Abstract
ANNOTATION The epithelium of the mucous membrane of the oral cavity, in particular the cheeks of a person, consists of stratified squamous non-keratinizing epithelium. Surface epithelial cells are updated due to the germ layer. Violation of the process of differentiation of cells of this epithelium is possible with various metabolic, hormonal changes, exposure to mechanical and physical factors, chemical and radioactive substances. We studied smears prepared from the epithelium of the cheeks of patients with COVID (buccal epithelium) and stained using the Papanicolaou method. It has been established that in patients with coronavirus infection, various changes in the structure of the nuclei of the buccal epithelium are often detected. In particular, cytogenetic disorders, which are more common in patients with moderate disease severity. Also, there is an increase in the proliferative activity of epithelial cells of the buccal mucosa. Patients with severe disease also show cytogenetic abnormalities. However, in addition, they have cytological signs of the initial and final phases of destruction of the nuclei of buccal epithelium cells.
Key words
Key words: cytology, buccal epithelium, COVID, cytogenetic disorders, mucosa, cheek.
Literature
1. Заболотная Н. В., Прядко А.О., Морозов В.Н., Михайлик Т.А., Морозова Е.Н. Микроскопические особенности буккального эпителия студентов-индусов в НИУ «БелГУ» // Научный результат. Серия Медицина и фармация. 2015. Т. 1, № 4. С. 42-49. 2. Молоканова Ю.П. Особенности цитоморфологии буккального эпителия курящих лицюношеского возраста // Вестник Московского государственного областного университета. Серия: Естественные науки. 2017. № 1. С. 21–30.DOI: 10.18384/2310-7189- 2017-1-21-30. 3. Cuevas-GonzalezM.V.,Espinosa-CristóbalL.F.,Donohue-CornejoA. etal. COVID-19 and its manifestations in the oral cavity: A systematic review Medicine (Baltimore).2021 Dec 23;100(51):e28327. doi: 10.1097/MD.0000000000028327. 4. G.C. Park,S.-Y. Bang,H.W.Lee,etal.ACE2 and TMPRSS2 immunolocalization and oral manifestations of COVID-19 // Oral Dis.2022 Jan 9.doi: 10.1111/odi.14126.Online ahead of print. 5. 5. OrozcoM.F.S.,Niño-MartínezN., Martínez-CastañónG.-A. et al. Presence of SARS-CoV-2 and Its Entry Factors in Oral Tissues and Cells: A Systematic Review// Medicina (Kaunas).2021 May 23;57(6):523. doi: 10.3390/medicina57060523.