Gepato-gastroeterologik tadqiqotlar jurnali 2021, №2 MAXSUS SON 1-TOM
Subject of the article
IMMUNOLOGICAL FEATURES OF INFECTIOUS MONONUCLEOSIS EPSTEIN-BARR VIRUS ETIOLOGY IN CHILDREN (93-95)
Authors
Mirzoeva M.R., Keldiyorova Z.D.
Institution
Bukhara State Medical Institute named after Abu Ali ibn Sino
Abstract
A comparative study of cytokines in clinically similar groups of patients requiring differential diagnostic search revealed significant differences in the level of indicators. At the height of the disease, the serum of children with infectious Epstein-Barr mononucleosis of viral etiology is characterized by an increase in the content of proinflammatory cytokines IL-1α (1.7 times), IL-β (1.6 times) and INF-γ (4.3 times).
Key words
infectious mononucleosis, bacterial tonsillitis, hepatitis B.
Literature
1. Boshyan R.E. Infection caused by the Epstein-Barr virus: epidemiological manifestations and laboratory diagnostics: author's abstract to the thesis of PhD of Medicine. - M., 2018 .– p 42. 2. Burmagina I. A., Pozdeeva M. A., Agafonov V. M. Infectious mononucleosis in the Northern region // Modern medicine: topical issues. - 2014. - No. 33. - p. 26-31. 3. Valishin D. A., Khunafina D. Kh., Murzabaeva R. T., Mamon A. P.et al. Differential diagnosis in infectious mononucleosis // Bulletin of the Bashkir State Medical University. - 2013. - No. 4. - p. 135-140. 4. Volokha A. P. Epstein-Barr viral infection in children // Modern Pediatrics. - 2015. - No. 4 (68). - p. 103. 5. Vygovskaya O. V., Kramarev S. A., Taradiy N. N. et al. Immune-pathogenesis with Epstein-Barr viral infection in children // Modern Pediatrics. - 2013. - No. 8 (56). - Sp 44. 6. Gileva R. A., Khokhlova Z. A., Chechet Yu. S. Clinical and laboratory characteristics of infectious mononucleosis caused by the Epstein-Barr virus // Kazan Medical Journal. - 2014. - No. 5. - T. 95. - p. 722-725 7. Goreyko T. V., Kalinina N. M., Drygina L. B. Modern concepts of immune-pathogenesis of infection caused by the Epstein-Barr virus // Infection and immunity. - 2017. - No. 2. - T. 1. - p. 121-130. 8. Jivitsa L. V., Ponomarenko G. F., Predeina V. A. Features of course of infectious mononucleosis in children and adults // Clinical medicine. - 2018 - No. 10. - p. 121-123. 9. Yokoyama T., Tokuhisa Y., Toga A., Fujiki T., Sakakibara Y., Mase S. et al. Agranulocytosis after infectious mononucleosis // J Clin Virol. - 2013. - No. 56 (3). - P. 271-273. 10. Ju M. H., Liang M., Wang Z. J., Wen H. Y. Value of antiviral therapy for infectious monocytosis in children // Jong-guo Dang Dai Er Ke Za Ji. - 2012. - No. 14(3). - Р. 198-201. 11. Zidovec Lepej S., Vince A., Dakovic Rode O. Increased numbers of CD 38 molekules on bright CD8+ T lymphocytes in infectious mononucleosis caused bi Epstein-Barr virus infection // Clin Exp Immunol. - 2013. - Vol. 133. - No. 3. - Р. 384-390. 12. Кeldiyorova.Z.D., Narzullaev N.U. Cytokine profile of children with acute inflammation of the palatine tonsil in acute infectious mononucleosis during treatment. Tibbiyotda yangi kun. No. 2 (30). Tashkent 2020, p. 459-461. 13. Кeldiyorova.Z.D. INFECTIOUS MONONUCLEOSIS DUE TO THE VIRUS EPSTEIN - BARR: CLINICAL AND PATHOGENETIC ASPECTS ACADEMICIA: An International Multidisciplinary Research Journal https://saarj.com ACADEMICIA ISSN: 2249-7137 Vol. 10, Issue 4, April 2020 Impact Factor: SJIF 2020 = 7.13 14. Oblokulov A.R., Elmuradova A.A., Farmanova M.A. Virologic response in the treatment of infection with antiviral drugs. // World Journal of Pharmaceutical Research. Volume 9, Issue 9, 87-92.