Kardiorespirator tadqiqotlar jurnali 2. 2021.pdf

Subject of the article

EFFECTS OF SMOKING ON CARDIOVASCULAR FUNCTION: THE ROLE OF NICOTINE AND CARBON MONOXIDE (26-33)

Authors

Sachin Kumar B., Tashkenbaeva E.N., Abdieva G.A.

Institution

Samarkand State Medical Institute

Abstract

Smoking is a widespread chance thing for all factors of cardiovascular disorder. It influences the myocardium and occludes the blood supply, will increase atherosclerosis and contributes to myocardial infarction, cardiomyopathy and peripheral vascular disorder. Nicotine, carbon monoxide and different tobacco elements have direct outcomes at the endothelium, inflicting inflammation, atheroma and thrombosis. Free radicals are ample in cigarette smoke and those provoke and accentuate the inflammatory cascade, growing leukocyte infiltration and cytokine production. It is essential to reap correct records approximately smoking habit, however records amassing ought to now no longer depend on self-record that is misleading, however ought to use a few shapes of biochemical biomarker, ideally cotinine. Smokers ought to then be intensively counselled, each through inresidence skilled personnel and thru the professional smoking cessation services. It ought to be defined to sufferers in fundamental phrases approximately the deleterious outcomes of smoking on coronary heart disorder and atherosclerosis. Patients ought to be recommended to apply all reasserts of counselling and to go to the substitute treatments or different pharmaceutical aids to quit. The purpose of this article is to provide a brief evaluation of the outcomes of smoking, and especially the outcomes of nicotine and co on cardiovascular function. Nicotine deactivates cardiac autonomic function, will increase empathy hobby, increases heart rate (HR) at relaxation, while blunting HR elevation all through innovative exercise and lowering the maximum HR that may be executed. On the equal time, the smoking- generated co binds with haemoglobin and myoglobin, reduces arterial 02 blood saturation, compromises the performance of respiratory enzymes, and reasons disorder of the 02 production, transportation and transport device, specially all through exercise, notably decreasing the purposeful capability and the overall performance of the circulatory machine.

Key words

heart disease, circulatory system, smoking, tobacco.

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