PBIM (137) № 4 2022

Maqola mavzusi

МАРКАЗИЙ НЕРВ ТИЗИМИ ПЕРИНАТАЛ ШИКАСТЛАНИШИ БИОМАРКЕРЛАРИНИНГ ДИАГНОСТИК ВА ПРОГНОСТИК АҲАМИЯТИ (294-301)

Mualliflar

Мамадалиев Абдураҳмон Маматқулович, Алиев Мансур Абдухолиқович, Мамадалиева Саодат Абдураҳмоновна, Тилавқулов Муҳиддин Содиқжон ўғли

Muassasa

Самарқанд давлат тиббиёт университети, Ўзбекистон Республикаси, Самарқанд ш.

Annotatsiya

Перинатал тиббиётда чақалоқлар бош мия тўқимаси ҳолатини баҳолашнинг кўп сонли усуллари бўлишига қарамасдан бош мия шикастланишининг эрта белгиларини аниқлаш замонавий тиббиётнинг жуда муҳим вазифаларидан бири бўлиб ҳисобланади. Марказий нерв системасининг (МНС) шикастланиш даражасини аниқлаш туғруқ вақтидаги краниоцеребрал травмалар, перинатал асфиксия, гипоксик-ишемик энцефалопатия ва интравентрикуляр қон қуйилишларида турли даволаш усулларининг натижаларини, шу билан биргаликда неврологик етишмовчиликлар ривожланиш хавфини баҳолашга имкон беради. МНС гипоксик травмаси асоратларини баҳолашда кенг қамровли биомаркерлар ўрганилади ва булар жумласига нейропротеинлар, кальций боғловчи оқсил, вазоактив моддалар, оксидатив стресс маркерлари, яллиғланиш медиаторлари киритилади. Маълумки бош мия шикастланишларида турли хил биологик суюқликларда қатор биомаркерларнинг концентрацияси ошади ва бу ҳолат туғруқ муддатига боғлиқ бўлмаган ҳолдаги шикастланишнинг ифодаланиши даражаси билан корреляция қилинади. Шундай қилиб, ушбу мақолада болаларда бош миянинг шикастланишини аниқлашда биомаркерларнинг аҳамиятини баҳолашга қаратилган адабиётлар таҳлили келтирилмоқда.

Kalit so'zlar

нейрон-специфик оқсиллар, биомаркерлар, перинатал гипоксия, туғруқ жараёни, краниоцеребрал травма.

Adabiyotlar

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