PBIM (137) № 4 2022

Maqola mavzusi

THE STATE OF REGIONAL BLOOD FLOW IN DIABETIC FOOT SYNDROME (279-283)

Mualliflar

Davlatov Salim Sulaymonovich, Khamdamov Bakhtiyor Zarifivich

Muassasa

Bukhara State Medical Institute, Republic of Uzbekistan, Bukhara

Annotatsiya

Diabetes mellitus (DM) in the world is recognized as one of the most important non-communicable diseases, the spread of which has acquired the character of a pandemic. Diabetic foot syndrome leads the list of late complications of diabetes, leading to early disability and determining a high mortality rate. In 2019, diabetes was the direct cause of 1.5 million deaths, and 48% of all diabetes-related deaths occurred before the age of 70. According to the International Diabetes Federation, from 25 to 47% of hospitalizations of patients with diabetes are associated with purulent-destructive lesions of the feet due to the development of chronic tissue ischemia. The review reflects the main pathophysiological mechanisms of microcirculation disorders in diabetic foot syndrome, leading to critical ischemia of the lower ex-tremities.

Kalit so'zlar

diabetes mellitus, diabetic foot syndrome, microangiopathy, macroangiopathy, ischemia, microcirculation.

Adabiyotlar

1. Rundo A. I. Modern aspects of etiology and pathogenesis of diabetic foot syndrome //Surgery news. - 2015. – Vol. 23. – No. 1. – P. 97-104. 2. Dubrovschik O. I. et al. Real possibilities of reducing the frequency of lower limb amputations in patients with purulent-necrotic complications of diabetic foot syndrome //Journal of Grodno State Medical University. – 2015. – №. 4 (52). – P. 26-29. 3. Pytskaya N. V. Laser extraction of complicated cataracts in patients with diabetes mellitus. Dissertation for the degree of Candidate of Medical Sciences. Moscow 2008. – 157 p. 4. Social A. Z. N. WHO. Newsletter. November 2021 //Social aspects of public health Founders: Central Research Institute of Organization and Informatization of Healthcare. – 2021. – Vol. 67. – No. 6. 5. Khamraeva F. M., Nazarova S. K., Fayzieva M. F. Actual problems of diabetes mellitus, improvement of diabetological care to the population at the regional level //Internauka. – 2020. – No. 19-1. – P. 69-70. 6. Boboev M. M., Yuldashev R. N. New diabetic centers in Uzbekistan: organization //Diabetes mellitus-2021: from monitoring to management. – 2021. – P. 26-27. 7. Vertkin A. Comorbid patient. A guide for practitioners. – Liters, 2022. – 150 p. 8. International Working Group on the Diabetic Foot et al. International Consensus on the Diabetic foot 2007 //Evidenzklasse IV. – 2007. 9. Kerimova L. N. et al. The use of an integrated approach in surgery for the treatment of diabetic foot syndrome //21st century: fundamental science and technology X. – 2016. – P. 23-26. 10. Babushkina Y. V. et al. Features of specialized care for patients with diabetic osteoarthropathy //Wounds and wound infections. The prof. BM Kostyuchenok journal. – 2019. – Т. 6. – №. 2. – Р. 6-16. 11. Krysanov I. S. Pharmacoeconomics of diabetes mellitus //Pharmacoeconomics. Modern pharmacoeconomics and pharmacoepidemiology. - 2009. – No. 1. – P. 42-47. 12. Zelenova O. V. et al. Patient model for surgical treatment and rehabilitation of diabetic foot syndrome //Wounds and wound infections. Journal named after Professor B. M. Kostyuchenka. – 2018. – Vol. 5. – No. 2. – P. 58-79. 13. Dedov I. I. et al. Results of the implementation of the subprogram "Diabetes mellitus" of the Federal Target Program "Prevention and control of socially significant diseases 2007-2012" //Diabetes mellitus. – 2013. – No. 2S. – P. 2-48. 14. Voynov A.V., Bedrov A. Ya., Voinov V. A. "diabetic foot" syndrome //Bulletin of surgery named after I. Grekov. - 2012. – Vol. 171. – No. 3. – P. 106-109. 15. Tyrheeva N. R., Manibadarova Ya. N. Evaluation of the effectiveness of conservative treatment in patients with diabetic foot syndrome //Acta Biomedica Scientifica. – 2008. – №. 4. – P. 128.. 16. Britvin A. A., Tseitlina E. F. Investigation of the clinical efficacy of the drug Glidiab (AOA Aakrikhin) in patients with type 2 diabetes mellitus //International Medical Journal. – 2001. – №. 6. – P. 526. 17. Ametov A. S., Soluyanova T. N. Treatment of late complications of diabetes mellitus: the role of Milgamma compositum //RMZH. – 2009. – Vol. 17. – no. 24. – P. 1604-1609. 18. National diabetes fact sheet: national estimates and general information on diabetes and prediabetes in the United States, 2011 / Centers for Disease Control and Prevention. - Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, 2011. 19. Diabetes Atlas. - Third edition. - International Diabetes Federation, 2007. - 381 p. 20. Bowker J. The Diabetic Foot, 6th edition /Ed. by J. Bowker, M Pfeifer (Eds.). - Mosby, 2001. – 365 p. 21. Mizin A., Udovichenko O., Terekhin S. Critical ischemia of the lower extremities and ischemic forms of diabetic foot syndrome. – Liters, 2018. – 160 p. 22. Zorkaltsev M. A. Modern aspects of radiation diagnosis of diabetic foot syndrome. Dissertation for the degree of Doctor of Medical Sciences. Tomsk – 2018. – 244 p. 23. Ignatovich I. N., Kondratenko G. G. Educational and methodical manual. Diabetic foot surgery. Minsk BSMU – 2013. – 58 p. 24. Zubarev, P.N., Ivanusa, S.Ya., Risman, B.V. Treatment of purulent-necrotic complications of diabetic foot syndrome: A textbook for students of the training of doctors, interns and postgraduate training systems in the specialty "Surgery"/P.N. Zubarev, S.Y. Ivanusa, B.V. Risman - St. Petersburg: Open Forum News Agency, 2015. - 36 p. 25. Ferenets M. V. The choice of timing and scope of sanitizing interventions after vascular reconstruction in patients with IV degree of lower limb ischemia. Dissertation for the degree of Candidate of Medical Sciences. Moscow 2016. – 165 p. 26. Dudanov I. P. et al. Atherosclerosis, diabetes mellitus and autonomous innervation of the organs of the cardiovascular system //Medical Academic Journal. – 2012. – Vol. 12. – No. 2. – P. 19-27. 27. Stepanova O. I. et al. Correction of pathogenetic disorders in type II diabetes mellitus by cell transplantation methods //Biomedicine. - 2005. – No. 1. – pp. 35-51. 28. Belousova O. N. et al. Molecular and genetic mechanisms of pathogenesis of type 2 diabetes mellitus //Actual problems of medicine. – 2015. – T. 31. – №. 16 (213). – P. 12-19. 29. Gurmikova N. L. Optimization of methods for the diagnosis of peripheral artery diseases in patients with diabetes mellitus: Abstract of the dissertation for the degree of Candidate of Medical Sciences. Moscow-2015. - 26 p. 30. Rozenkova T. V. Prospects for performing distal arterialization and hemodynamic criteria for its effectiveness in critical lower limb ischemia //Regional blood circulation and microcirculation. - 2007. – Vol. 6. – No. 4. – P. 4-13. 31. Chur N. N. Treatment of patients with chronic lower limb ischemia in diabetes mellitus //Surgery news. - 2008. – Vol. 16. – No. 1. – P. 134-139. 32. Bregovsky V. B. et al. Diabetic distal polyneuropathy review of current recommendations //Annals of Clinical and Experimental Neurology. - 2015. – Vol. 9. – No. 1. – pp. 60-68. 33. Khamdamov B. Z. Indicators of immunocitocine status in purulent-necrotic lesions of the lover extremities in patients with diabetes mellitus //American Journal of Medicine and Medical Sciences. – 2020. – Т. 10. – №. 7. – Р. 473-478. 34. Tuttolomondo A., Maida C, Pinto A. Diabetic foot syndrome as a possible cardiovascular marker in diabetic patients // J. Diabetes Res. - 2015. - 2015. - 268390. doi: 10.1155/2015/268390. 35. Sadykova K., Scenderova S. Общая вязкость крови при нарушениях углеводного и липидного обмена (Литературный обзор) //A. Âsaui atyndaġy Halyk̦aralyk̦ k̦azak̦-tùrìk universitetìnìn̦ habaršysy. – №. 105. – С. 39-45. 36. Yakutina N. V. Correction of endothelial dysfunction and microcirculatory disorders in patients with arterial hypertension in combination with type 2 diabetes mellitus //Russian Journal of Cardiology. – 2007. – №. 6. – Pp. 27-30. 37. Khamdamov B. et al. An integrated approach to the treatment of purulent-necrotic lesions of the lower extremities against the background of diabetes mellitus //Journal of Problems of Biology and Medicine. – 2017. – №. 3 (96). – Pp. 105-109. 38. Bondarenko O. N., Galstyan G. R., Dedov I. I. Features of the clinical course of critical lower limb ischemia and the role of endovascular revascularization in patients with diabetes mellitus //Diabetes mellitus. – 2015. – Vol. 18. – No. 3. – pp. 57-69. 39. Gaziev K. U. et al. Amputations at the shin level in critical ischemia in patients with diabetes mellitus //Biology and integrative medicine. – 2021. – №. 1 (48). – P. 34-43. 40. Gavrilenko A.V., Kotov A. E., Loikov D. A. Results of treatment of critical lower limb ischemia in patients with diabetes mellitus //Annals of Surgery. - 2013. – No. 6. – P. 48-51. 41. Drozhzhin E. V. et al. Features of hemocoagulation disorders in patients with the syndrome of critical ischemia of the lower extremities on the background of diabetes mellitus //Bulletin of the National Medical and Surgical Center named after NO Pirogov. - 2018. – Vol. 13. – No. 1. – P. 49-52. 42. Boulton A. J. M., Scarpello J. H. B., Ward J. D. Venous oxygenation in the diabetic neuropathic foot: evidence of arteriovenous shunting? //Diabetologia. – 1982. – Т. 22. – №. 1. – Р. 6-8. 43. Boulton A. J. M., Malik R. A. Diabetic neuropathy //Medical Clinics of North America. – 1998. – Т. 82. – №. 4. – Р. 909-929. 44. Tral T. G. et al. Molecular and morphological features of the formation of chronic placental insufficiency caused by different types of diabetes mellitus // Diabetes mellitus. – 2020. – Vol. 23. – No. 2. – pp. 189-195. 45. Biryukova E. V., Shinkin M. V. Diabetic macroangiopathies: mechanisms of development, approaches to therapy. Clinical ophthalmology. - 2018. – Vol. 18. – No. 2. – P. 91-96.