PBIM 2022 №6 (140)

Maqola mavzusi

РОЛЬ ВОСПАЛИТЕЛЬНЫХ ФАКТОРОВ НА РАЗВИТИЕ ХРОНИЧЕСКОЙ ИШЕМИИ МОЗГА У ПАЦИЕНТОВ C САХАРНЫМ ДИАБЕТОМ 2 ТИПА (365-367)

Mualliflar

Наджмитдинов Отабек Бахритдин угли1, Усманова Дурдона Джурабаевна2

Muassasa

1 - Андижанский государственный медицинский институт, Республика Узбекистан, г. Андижан; 2 - Ташкентский педиатрический медицинский институт, Республика Узбекистан, г. Ташкент

Annotatsiya

Хроническая ишемия мозга (ХИМ) является одной из ведущих причин развития инсульта. Вследствие хронического нарушения мозгового кровообращения развивается воспалительный ответ, ха-рактеризующийся активацией и высвобождением ци-токинов, хемокинов, молекул адгезии и протеолитиче-ских ферментов, которые в свою очередь способству-ют повреждению структур головного мозга. ХИМ протекает хуже среди диабетиков, что приводит к увеличению смертности и инвалидности.

Kalit so'zlar

Хроническая ишемия мозга, сахарный диабет.

Adabiyotlar

1. Guariguata L. et al Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract. 2014;103:137–49. 2. Cryer PE. Hypoglycemia, functional brain failure, and brain death. J Clin Invest. 2007;117:868–70. 3. Tamborlane WV et al. Continuous glucose monitoring and intensive treatment of type 1 diabetes. N Engl J Med. 2008;359:1464–76. 4. Gehlaut RR. et al Hypoglycemia in type 2 diabetes—more common than you think: a continuous glucose monitoring study. J Diabetes Sci Technol. 2015;9:999–1005. 5. Seaquist ER. et al. Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society. Diabetes Care. 2013;36:1384–95. 6. Shafiee G. et al The importance of hypoglycemia in diabetic patients. J Diabetes Metab Disord. 2012;11:17. 7. Roberts RO. et al Association of duration and severity of diabetes mellitus with mild cognitive impairment. Arch Neurol. 2008;65:1066–73. 8. Blasetti A. et al The effect of recurrent severe hypoglycemia on cognitive performance in children with type 1 diabetes: a meta-analysis. J Child Neurol. 2011;26:1383–91. 9. Joy NG. et al Effects of acute hypoglycemia on inflammatory and pro-atherothrombotic biomarkers in individuals with type 1 diabetes and healthy individuals. Diabetes Care. 2010;33:1529–35. 10. Van Dieren S. et al The global burden of diabetes and its complications: an emerging pandemic. Eur J Cardiovasc Prev Rehabil. 2010;17 Suppl 1:S3–8. 11. Wrighten SA. et al A look inside the diabetic brain: contributors to diabetes-induced brain aging. Biochim Biophys Acta. 2009;1792:444-453. 12. Luitse MJ. et al Diabetes, hyperglycaemia, and acute ischaemic stroke. Lancet Neurol. 2012;11:261–71. 13. Sarwar N. et al. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet. 2010;375:2215–22. 14. Cui R, Iso H, Yamagishi K, Saito I, Kokubo Y, Inoue M, Tsugane S. Diabetes mellitus and risk of stroke and its subtypes among Japanese: the Japan public health center study. Stroke. 2011;42:2611–4. 15. Huxley RR, Filion KB, Konety S, Alonso A. Meta-analysis of cohort and case-control studies of type 2 diabetes mellitus and risk of atrial fibrillation. Am J Cardiol. 2011;108:56–62. 16. Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, et al. Heart disease and stroke statistics—2012 update: a report from the American Heart Association. Circulation. 2012;125:e2–e220. 17. Prakash R, Somanath PR, El-Remessy AB, Kelly-Cobbs A, Stern JE, Dore-Duffy P, Johnson M, Fagan SC, Ergul A. Enhanced cerebral but not peripheral angiogenesis in the Goto-Kakizaki model of type 2 diabetes involves VEGF and peroxynitrite signaling. Diabetes. 2012;61:1533–42. 18. Luan H, Kan Z, Xu Y, Lv C, Jiang W. Rosmarinic acid protects against experimental diabetes with cerebral ischemia: relation to inflammation response. J Neuroinflammation. 2013;10:28. 19. Tureyen K, Bowen K, Liang J, Dempsey RJ, Vemuganti R. Exacerbated brain damage, edema and inflammation in type-2 diabetic mice subjected to focal ischemia. J Neurochem. 2011;116:499–507. 20. Dave KR, Tamariz J, Desai KM, Brand FJ, Liu A, Saul I, Bhattacharya SK, Pileggi A. Recurrent hypoglycemia exacerbates cerebral ischemic damage in streptozotocin-induced diabetic rats. Stroke. 2011;42:1404–11. 21. Smith CJ, Lawrence CB, Rodriguez-Grande B, Kovacs KJ, Pradillo JM, Denes A. The immune system in stroke: clinical challenges and their translation to experimental research. J Neuroimmune Pharmacol. 2013;8:867–87. 22. Woodruff TM, Thundyil J, Tang SC, Sobey CG, Taylor SM, Arumugam TV. Pathophysiology, treatment, and animal and cellular models of human ischemic stroke. Mol Neurodegener. 2011;6:11.