Doktor axborotnomasi 2025, № (117)

Maqola mavzusi

SUBACUTE SCLEROSING PANENCEPHALITIS IN CHILDREN (176-182)

Mualliflar

Sh. Kh. Saidazizova, F. U. Inomov

Muassasa

Center for the development of professional qualifications of medical workers, Tashkent, Uzbekistan

Annotatsiya

Subacute Sclerosing Panencephalitis (SSPE) is a progressive, fatal neurodegenerative disease caused by persis tent infection with a mutated measles virus. This literature review examines the historical, clinical, epidemiological, and immunological aspects of SSPE, emphasizing the role of early diagnosis and vaccination. Despite advancements in antiviral and immunomodulatory therapies, effective treatment remains elusive, highlighting the need for ongoing research and public health measures. The review underscores the critical importance of sustained measles immuniza tion programs to prevent the resurgence of SSPE in vulnerable populations.

Kalit so'zlar

subacute sclerosing panencephalitis, measles virus, neurological disorders, immunization, pediatric neu rodegeneration.

Adabiyotlar

1. Pandey N. et al. A comprehensive expedition of tauopathies in subacute sclerosing panencephalitis (SSPE): a nar rative review // Egypt J Neurol Psychiatry Neurosurg. 2024. Vol. 60, № 1. P. 96. 2. Aicha Hanna. Brain tropism acquisition: the spatial dynamics and evolution of a measles virus collective infectious unit that drove lethal subacute sclerosing panencephalitis. 2024. 3. Cornelius L.P. et al. Clinical, Demographic, Neuro Imaging Features, and Outcome of Subacute Sclerosing Pan Encephalitis in a Pediatric Cohort // Journal of Pediatric Neurosciences. 2023. Vol. 18, № 2. P. 147. 4. Kocaağa A. The immunogenetics of subacute sclerosing panencephalitis: A comprehensive review // KPJ. 2022. Vol. 36. P. 151–154. 5. Papetti L. et al. Subacute Sclerosing Panencephalitis in Children: The Archetype of Non-Vaccination: 4 // Viruses. Multidisciplinary Digital Publishing Institute, 2022. Vol. 14, № 4. P. 733. 6. Hidayah N., Wijaya A.B. Diagnostic Approaches and Management of Subacute Sclerosing Panencephalitis in Children // J. Berk. Ked. 2020. Vol. 16, № 2. P. 141. 7. Garg R.K. et al. Subacute sclerosing panencephalitis: 5 // Rev Med Virol. 2019. Vol. 29, № 5. P. e2058. 8. Mekki M. et al. Subacute sclerosing panencephalitis: clinical phenotype, epidemiology, and preventive interven tions: 10 // Dev Med Child Neurol. 2019. Vol. 61, № 10. P. 1139–1144. 9. Mohandeep Kaur et al. Subacute sclerosing panencephalitis - A fatal complication of measles // Indian Journal of Clinical Anaesthesia. 2020. Vol. 5, № 1. P. 159–161. 10. Paul A. Rota et al. Subacute Sclerosing Panencephalitis. // Clinical Infectious Diseases. 2017. Vol. 65, № 2. P. 233–234. 11. Zoe Rocke, Mariya Belyayeva. Subacute Sclerosing Panencephalitis. 2021. 12. Helen Campbell et al. Review of the effect of measles vaccination on the epidemiology of SSPE // International Journal of Epidemiology. 2007. Vol. 36, № 6. P. 1334–1348. 13. Lauren A. O’Donnell, James F. Bale. Measles Virus and Subacute Sclerosing Panencephalitis. 2016. P. 27–43. 14. Jose Gutierrez, Richard S Issacson, Barbara S. Koppel. Subacute sclerosing panencephalitis: an update. // Devel opmental Medicine & Child Neurology. 2010. Vol. 52, № 10. P. 901–907. 15. Keiji Nihei, Nihei K. Epidemiological aspects of SSPE // Nihon rinsho. Japanese journal of clinical medicine. 2007. Vol. 65, № 8. P. 1460–1465. 16. Hak Hotta et al. SSPE virus and pathogenesis // Nihon rinsho. Japanese journal of clinical medicine. 2007. Vol. 65, № 8. P. 1475–1480. 17. Stefka Krumova et al. Measles Virus and Subacute Sclerosing Panencephalitis. // Clinical Laboratory. 2022. Vol. 68 9. 18. Paul Richard Dyken. Some aspects about the clinical and pathogenetic characteristics of the presumed persistent measles infections: SSPE and MINE // Journal of pediatric neurology. 2015. Vol. 02, № 03. P. 121–124. 19. Samia P. et al. Options in the Treatment of Subacute Sclerosing Panencephalitis: Implications for Low Resource Areas: 3 // Curr Treat Options Neurol. 2022. Vol. 24, № 3. P. 99–110. 20. Jacob Valk, Marjo S. van der Knaap. Subacute Sclerosing Panencephalitis. 1989. P. 221–224. 21. Prakash Chandra Ghosh et al. Early onset subacute sclerosing panencephalitis in indian children: a case series highlighting an alarming trend and the need to re-assess the current vaccination strategies // International journal of scientific research. 2021. P. 66–69. 22. Kavita Srivastava, Ekta Agarwal, Surekha Rajadhyaksha. Resurgence of Subacute Sclerosing Panencephalitis: Case Series and Global Epidemiological Trends // Journal of pediatric neurology. 2021. 23. Neha Kamran, Fatima Jehangir. A debilitating complication of measles virus: sspe. 2019. Vol. 8, № 1. P. 3–3. 24. Muhammad Akram et al. Clinical profile of subacute sclerosing panencephalitis. // Jcpsp-journal of The College of Physicians and Surgeons Pakistan. 2008. Vol. 18, № 8. P. 485–488. 25. Tushar Premraj Raut et al. Unusual presentation of more common disease/injury Evolution of certain typical and atypical features in a case of subacute sclerosing panencephalitis. 2012. 26. Sumeet R Dhawan et al. Fulminant Early Onset Subacute Sclerosing Panencephalitis // Indian Journal of Pediat rics. 2017. Vol. 84, № 2. P. 154–155. 27. Sujit Jagtap, Nair, Harsha J Kambale. Subacute sclerosing panencephalitis: A clinical appraisal // Annals of Indian Academy of Neurology. 2013. Vol. 16, № 4. P. 631–633. 28. Serdar Cömert et al. Subacute sclerosing panencephalitis presenting as acute disseminated encephalomyelitis. // Indian Journal of Pediatrics. 2006. Vol. 73, № 12. P. 1119–1121. 29. L. Lujić. Subacute sclerosing panencephalitis – variety of clinical presentations // Paediatria Croatica. 2008. Vol. 52, № 3. 30. Takashi Ichiyama. Clinical course and findings in and differential diagnosis of subacute sclerosing panencephali tis // Nihon rinsho. Japanese journal of clinical medicine. 2007. Vol. 65, № 8. P. 1481–1482. 31. Hoppen T., Jacobi G., Rister M. Subacute sclerosing panencephalitis (SSPE) // Klinische Padiatrie. 2003. Vol. 215, № 5. P. 268–269. 32. G. Ebinger, G. Matthyssens. Cerebrospinal fluid measles antibody titer and globulins in subacute sclerosing panen cephalitis. 1971. Vol. 200, № 1. P. 1–5. 33. Prateek Kumar Panda et al. Association Between Clinical Severity, Neuroimaging, and Electroencephalographic Findings in Children with Subacute Sclerosing Panencephalitis // Journal of Child Neurology. 2024. 34. Srikanteshwara Praveen-Kumar et al. The spectrum of MRI findings in subacute sclerosing panencephalitis with clinical and EEG correlates // Journal of pediatric neurology. 2015. Vol. 09, № 02. P. 177–185. 35. Atypical imaging and clinical presentation of fulminant subacute sclerosing panencephalitis. 2023. Vol. 1. P. 21 24. 36. Banu Anlar. Subacute sclerosing panencephalitis : diagnosis and drug treatment options. // CNS Drugs. 1997. Vol. 7, № 2. P. 111–120. 37. Vijayavarman V. et al. Immune-dysregulation in subacute sclerosing panencephalitis: An exploratory case–control study // Journal of Medical Virology. 2023. Vol. 95, № 2. P. e28504. 38. V. S. Varman et al. Primary Immune Dysregulation in Subacute Sclerosing Panencephalitis: A Case-Control Study // Neurology. 2022. Vol. 99, № 23 Supplement 2. P. S48–S49. 39. Ankkita Sharma Bhandari et al. Subacute sclerosing panencephalitis with a fulminant course: Case series // Cur rent Medicine Research and Practice. 2024. Vol. 14, № 4. P. 174–177. 40. Athira Mohan S, Anoop V Somarajan, Dhanya Dharman. Subacute sclerosing panencephalitis (SSPE): Late onset of measles complication - Case of IVIG treatment failure. 2023. 41. Daniel J. Bonthius. Measles Virus and the Central Nervous System: An Update. // Seminars in Pediatric Neurolo gy. 2023. Vol. 47. P. 101078–101078. 42. Hashimoto K., Hosoya M. Advances in Antiviral Therapy for Subacute Sclerosing Panencephalitis: 2 // Molecules. 2021. Vol. 26, № 2. P. 427. 43. Akemi Tomoda et al. [Trial of intraventricular ribavirin and interferon-alpha combination therapy for subacute sclerosing panencephalitis (SSPE) in Japan]. // No to hattatsu. Brain and development. 2003. Vol. 35, № 4. P. 321–326. 44. Mitsuaki Hosoya et al. High-Dose Intravenous Ribavirin Therapy for Subacute Sclerosing Panencephalitis // Anti microbial Agents and Chemotherapy. 2001. Vol. 45, № 3. P. 943–945. 45. Horiguchi Y, Ohya T. [Successful treatment of subacute sclerosing panencephalitis with long-term intrathecal large dose of alpha-interferon--a case report]. // No to hattatsu. Brain and development. 1995. Vol. 27, № 3. P. 231-237. 46. Minsun Kwak et al. A long-term subacute sclerosing panencephalitis survivor treated with intraventricular interfer on-alpha for 13 years // Korean Journal of Pediatrics. 2019. Vol. 62, № 3. P. 108–112. 47. Roosy Aulakh. Subacute sclerosing panencephalitis: promising results with intraventricular interferon alpha 2b therapy and intraventricular ribavarin therapy // Pediatric Review: International Journal of Pediatric Research. 2018. Vol. 5, № 6. P. 306–307. 48. Hosoya M. [Anti SSPE drugs]. // Nihon rinsho. Japanese journal of clinical medicine. 2012. Vol. 70. P. 625–628. 49. Pritha A., Medha T.N., Garg R.K. A Comprehensive Investigation of the Current Subacute Sclerosing Panenceph alitis (SSPE) Treatment Options to Improve Patient Quality of Life: 8 // Cureus. 2024. Vol. 14, № 8. P. e28389. 50. Elena Bozzola et al. Global Measles Epidemic Risk: Current Perspectives on the Growing Need for Implementing Digital Communication Strategies. // Risk Management and Healthcare Policy. 2020. Vol. 13. P. 2819–2826. 51. Ross D. Silverman. Controlling Measles through Politics and Policy. // Hastings Center Report. 2019. Vol. 49, № 3. P. 8–9. 52. Matthew Bullen, George S. Heriot, Euzebiusz Jamrozik. Herd immunity, vaccination and moral obligation // Jour nal of Medical Ethics. 2023. P. jme-108485. 53. Alexander Doroshenko, Scott A. Halperin. Vaccination: the importance of herd immunity // Pediatric Health. 2007. Vol. 1, № 1. P. 35–42. 54. Gholam Ali Ghorbani. Mass Measles Vaccination // Iranian Journal of Medical Sciences. 2012. Vol. 37, № 3. P. 214–215. 55. Black Fl. The role of herd immunity in control of measles. // Yale Journal of Biology and Medicine. 1982. Vol. 55. P. 351–360. 56. Justin Lessler et al. Impact on Epidemic Measles of Vaccination Campaigns Triggered by Disease Outbreaks or Serosurveys: A Modeling Study. // PLOS Medicine. 2016. Vol. 13, № 10. 57. Meenal Garg et al. Subacute Sclerosing Panencephalitis (SSPE): Experience from a Tertiary-Care Pediatric Cen ter // Journal of Neurosciences in Rural Practice. 2022. Vol. 13. P. 315–320. 58. Klajdi Puka, Lauryn Conway, Mary Lou Smith. Quality of life of children and families // Handbook of Clinical Neurology. 2020. Vol. 174. P. 379–388. 59. Fartun Abdullahi H Orey, Abdirahman Omar Sahal, Bashiru Garba. Fatal subacute sclerosing panencephalitis in an 8-year-old male: a case report // The Pan African medical journal. 2023. Vol. 45. 60. Garg R.K. Subacute sclerosing panencephalitis // J Neurol. 2008. Vol. 255, № 12. P. 1861–1871. 61. Divyani Garg, Suvasini Sharma. Disease-Modifying Therapy in Subacute Sclerosing Panencephalitis: An Area of Darkness // Annals of Indian Academy of Neurology. 2023. Vol. 26, № 0. P. 3–9. 62. Banu Anlar. Subacute sclerosing panencephalitis and chronic viral encephalitis. // Handbook of Clinical Neurolo gy. 2013. Vol. 112. P. 1183–1189. 63. MD Banu Anlar. Subacute sclerosing panencephalitis // Paediatria Croatica. 2012. 64. Kavita J Rawat, Vrinda K Kulkarni. Subacute Sclerosing Panencephalitis (SSPE) - A Preventable Disaster. 2010.