Biomeditsina va amaliyot jurnali, 2023 №1

Maqola mavzusi

ANEMIA IN PREGNANT WOMEN WITH RHEUMATOID ARTHRITIS (9-16)

Mualliflar

Khasanova A. Dilafruz

Muassasa

Samarkand State Medical University

Annotatsiya

Objective: determine the value of the level of anemia in pregnant women with rheumatoid arthritis. Materials and Methods: The study was conducted on 100 pregnant women with a history of rheumatoid arthritis who were treated in the maternity complex of the first multidisciplinary clinic of Samarkand State Medical University during 2020-2022. The study used general clinical, laboratory (hematological, biochemical, immunological), instrumental and statistical methods of research. Results: All women with rheumatoid arthritis were divided into 2 groups according to hematological parameters: control - 20 women without anemia, and the main group - 80 women who were diagnosed with anemia according to hematological parameters. The type and degree of anemia in pregnant women with rheumatoid arthritis was determined in accordance with the classification recommended by WHO. Anemia of chronic diseases was observed in 56.25%, iron deficiency anemia in 40%, and in 3 women (3.75%) of the main group, the presence of both types of anemia was determined. Conclusions. All pregnant women with rheumatoid arthritis from the main group were diagnosed with anemia of various forms and degrees, which are characterized by a relationship between the duration, activity and radiographic manifestations of the disease.

Kalit so'zlar

Keywords: ferritin, anemia of chronic disease, iron deficiency anemia, haptoglobin phenotype, rheumatoid arthritis (RA), anemia, pregnancy.

Adabiyotlar

Авдеева A.C. (и др.). Генно-инженерные биологические препараты в лечении ревматоидного артрита // под ред. Е.Л. Насонова. - М.: Изд. группа «ИМА-ПРЕСС», 2013. - 552 с. 2. Ахтамова О. Ф. ANTIPHOSPHOLIPID SYNDROME AND MISCARRIAGE //УЗБЕКСКИЙ МЕДИЦИНСКИЙ ЖУРНАЛ. – 2022. – Т. 3. – №. 4. 3. Бенца, Т.М. Особенности клинического течения анемии у пациентов с ревматоидным артритом // Гематология. Трансфузиология. Восточная Европа. - 2015. - № 4. - С. 99-104 4. Ватутин Н.Т., Калинкина Н.В., Смирнова А.С. Анемия при ревматоидном артрите // Вестник Харьковского национального университета имени В.Н. Каразина. Серия «Медицина» 2010 №898 стр 76-82 5. Галушко Е.А., Беленький Д.А., Александрова Е.Н. [и др.] Роль гепсидина в развитии анемии у больных ревматоидным артритом // Научно-практическая ревматология. - 2012. - № 3. - С. 19-24. 6. Галушко Е.А., Левина А.А., Муравьев Ю.В. Дифференциальная диагностика характера анемии при ревматоидном артрите // Науч-практич ревматол 2003; 3:23–6. 7. Каратеев Д.Е. Острые вопросы стратегии лечения ревматоидного артрита // Современная ревматология, 2015, 1: 84-92. 8. Каратеев Д.Е., Лучихина Е.Л. Современные принципы –ведения больных с ревматоидным артритом // Медицинский совет • №17, 2017 стр 92-100 9. Каратеев ДЕ, Насонов ЕЛ, Сатыбалдыев АМ. Общероссийский регистр паци-ентов с ревматоидным артритом: настоящее и будущее // Современная ревматоло-гия. 2014;(1):84–6. 10. Сигидин ЯА, Лукина ГВ. Обобщенный анализ результатов генно-инженерной биологической терапии – поиски новых закономерностей // Научно-практическая ревматология. 2013;51(5):476–80. 11. Синяченко О. В., Петренко Е. А., Науменко Н. В. Зависимость течения ревматоидного артрита от экологии атмосферы регионов проживания больных // Журнал «Боль. Суставы. Позвоночник. – Киев, 2011. – Т. 4. – С. 04. 12. ХАСАНОВА Д. А. АУТОИММУННЫЙ ТИРЕОИДИТ: БЕРЕМЕННОСТЬ И РОДЫ //ЖУРНАЛ БИОМЕДИЦИНЫ И ПРАКТИКИ. – 2022. – Т. 7. – №. 5. 13. Aletaha D, Blüml S. Therapeutic implications of autoantibodies in rheumatoid arthritis. RMD Open. 2016 May 17;2(1):e000009. doi: 10,1136/rmdopen-2014-000. 14. Ben-Hadj-Mohamed M., Khelil S., Ben Dbibis M., Khlifi L., Chahed H., Ferchichi S., Bouajina E., Miled A. Hepatic Proteins and Inflammatory Markers in Rheumatoid Arthritis Patients. Iran J Public Health. 2017 Aug; 46 (8):1071–1078. 15. Bergrath E, Gerber RA, Gruben D, Lukic T, Makin C, Wallenstein G. Tofacitinib versus Biologic Treatments in Moderate-to-Severe Rheumatoid Arthritis Patients Who Have Had an Inadequate Response to Nonbiologic DMARDs: Systematic Literature Review and Network Meta-Analysis. Int J Rheumatol. 2017;2017:8417249. doi: 10,1155/2017/8417249. 16. Bianchi G, Caporali R, Todoerti M, Mattana P. Methotrexate and rheumatoid arthritis: current evidence regarding subcutaneous versus oral routes of administration. Adv Ther. 2016;33(3):369–378. 17. Bhala N, Emberson J, Merhi A, Abramson S, Arber N, Baron JA, et al. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet. 2013;382:769–79. doi: 10,1016/S0140- 6736(13)60900-9. 18. Branco JC, Barcelos A, de Araújo FP, et al. Utilization of subcutaneous methotrexate in rheumatoid arthritis patients after failure or intolerance to oral methotrexate: a Multicenter Cohort Study. Adv Ther. 2016;33(1):46–57. 19. Buckley F, Finckh A, Huizinga TWJ, et al. Comparative efficacy of novel DMARDs as monotherapy and in combination with methotrexate in rheumatoid arthritis patients with inadequate response to conventional DMARDs: a network meta-analysis J Man Care Spec Pharm 2015; 21: 409-423. DOI:10,18553/jmcp.2015,21,5,409. 20. Choy E, Aletaha D, Behrens F, Finckh A, Gomez-Reino J, Gottenberg JE, Schuch F, Rubbert- Roth A. Monotherapy with biologic disease-modifying anti-rheumatic drugs in rheumatoid arthritis. Rheumatology (Oxford) 2016 Aug 21. pii: kew271. 21. Doniyorovna K. D. et al. AUTOIMMUNE THYROIDITIS AND IODINE DEFICIENCY //ResearchJet Journal of Analysis and Inventions. – 2022. – Т. 3. – №. 7. – С. 1-6. 22. Gottheil S, Thorne JC, Schieir O, et al. Early use of subcutaneous MTX monotherapy vs. MTX oral or combination therapy significantly delays time to initiating biologics in early RA. Arthritis Rheumatol. 2016 68(suppl 10). 23. Fozilovna A. O., Raximovna X. D. ANTIPHOSPHOLIPIID SYNDROME AND MISSION OF PREGNANCY //UMUMINSONIY VА MILLIY QАDRIYATLАR: TIL, TА’LIM VА MАDАNIYAT. – 2022. – Т. 1. – С. 13-15. 24. Khasanova D. PREMENSTRUAL SYNDROME IN THE MODERN SCIENCE //International Bulletin of Medical Sciences and Clinical Research. – 2022. – Т. 2. – №. 12. – С. 16-22. 25. Khudoyarova, D. R. Improvement of methods of natural fertility restoration in women with infertility caused by endometriosis / D. R. Khudoyarova, Z. A. Kobilova, S. A. Shopulotov // Здоровье, демография, экология финно-угорских народов. – 2020. – No 4. – P. 53-55. – EDN YGGDOO. 26. Khudoyarova Dildora Rakhimovna, & Shopulotova Zarina Abdumuminovna. (2022). VACUUM - EXTRACTION OF THE FETUS BY DIFFERENT METHODS. Academicia Globe: Inderscience Research, 3(06), 238–240. https://doi.org/10.17605/OSF.IO/A3MS9 27. Kuruvilla J. Aplastic anemia following administration of a tumor necrosis factor-alpha inhibitor / J. Ku-ruvilla, H.A. Leitch, L.M. Vickars // Eur J Haematol. - 2003. - № 5. - P. 396-398 28. Lopez-Olivo MA, Siddhanamatha HR, Shea B, Tugwell P, Wells GA, Suarez-Almazor ME. Methotrexate for treating rheumatoid arthritis. Cochrane Database Syst Rev. 2014;6:CD000957. 29. Manolov V., Paskaleva-Peycheva V., Velizarova M., Ata-nasova B., Hadjidekova S., Vasilev V., Tzatchev K., Mari- nov B., Bogov I., Genchev G., Emilova R. Correlation between DAS28 and serum hepcidin levels in patients with anemia and rheumatoid arthritis. IJSR. 2015;4(1): 859-861. 30. Nies JAB, Krabben A, Schoones JW et al. What is the evidence for the presence of a therapeutic window of opportunity in rheumatoid arthritis? A systematic literature review. Ann Rheum Dis, 2014, 73: 861-870. doi: 10.1136/annrheumdis-2012-203130 31. Pulatov U., Hamdullaev M. LUS THERAPY IN PREGNANT WOMEN WITH CHRONIC RHINOSINUSITIS //Zamonaviy dunyoda tabiiy fanlar: Nazariy va amaliy izlanishlar. – 2022. – Т. 1. – №. 18. – С. 37-40. 32. Raj D.S. Role of Interleukin-6 in the Anemia of Chronic Disease / D.S Raj // Semin Arthritis Rheum. -2009,-№5.-P. 382-388 33. Rizaev J.A., Ahrorova M.Sh., Kubaev A.S., Hazratov A.I.; ,Morphological Changes in the Oral Mucous Membrane in Patients with COVID-19,American Journal of Medicine and Medical Sciences, 12, 5, 466-470, 2022 34. Rizaev Alimjanovich, Jasur; Shavkatovna, Akhrorova Malika; Saidolimovich, Kubaev Aziz; Isamiddinovich, Khazratov Alisher; ,CLINICAL AND IMMUNOLOGICAL ASPECTS OF THE RELATIONSHIP OF THE ORAL CAVITY AND COVID-19, Thematics Journal of Education, 7, 2, 2022 35. Shaxanova Sh Sh, Raximov N.M. Improving the combined treatment tactics of many osteogen metastases of malignant tumors of the urinary-body system. Web of Scientist: International Scientific Research Journal 2022/4/30, P 1145-1149. 36. Shodikulova G. Z. et al. The Correlation among Osteoporosis, Calcium-Phosphore Metabolism and Clinical Symptoms of Main Disease in Patients with Rheumatoid Arthritis //Annals of the Romanian Society for Cell Biology. – 2021. – С. 4185-4190. 37. Shodikulova G. Z., Pulatov U. S. EFFICIENCY EVALUATION OF TREATMENTS PATIENTS WITH RHEUMATOID ARTHRITIS BY DEPENDENCE OF CLINIC COURSE AND GENETIC POLYMORPHISM OF HAPTOGLOBINS //Toshkent tibbiyot akademiyasi axborotnomasi. – 2020. – №. 1. – С. 175-178. 38. Махмонов Л.С., Ризаев Ж.А., Гадаев А.Г. HELICOBACTER PYLORI И ЕГО ВАЖНОСТЬ ПРИ РАЗВИТИИ АНЕМИИ СВЯЗАННОЙ С ДЕФИЦИТОМ ЖЕЛЕЗА И ВИТАМИН В12// Проблемы биологии и медицины. - 2021. №5. Том. 130. - С. 215-218. 39. Rizaev A. Jhasur, Makhmonov S. Lutfulla, Gadaev G. Abdugaffor, Turakulov I. Rustam. Assessment of external factors involved in prediction of iron deficiency anemia associated with Helicobacter Pylori. Journal of Biomedicine and Practice. 2022, vol.7, issue 4, pp. 436-446 40. J.A. Rizaev, I.R.Agababyan, Y.A.Ismoilova ACTIVITIES OF CLINICS 41. SPECIALIZING IN THE TREATMENT OF PATIENTS WITH CHRONIC HEART DISEASE IN THE WORLD (REFERENCES). Journal of Biomedicine and Practice. 2021, vol. 6, issue 6, pp. 184-191 42. Ризаев, Ж., & Юнусханова, К. (2021). Патобиологические взаимодействия ревматоидного артрита и заболевания пародонта. Медицина и инновации, 1(2), 37–40. 43. Alimdjanovich, Rizayev Jasur, Agababyan Irina Rubenovna, and Ismoilova Yulduz Abduvokhidovna. "SPECIALIZED CENTER FOR THE PATIENTS WITH CHRONIC HEART FAILURE-EXTENSION OF LIFE." Вопросы науки и образования 22 (147) (2021): 14-24