Biomeditsina va amaliyot jurnali, 2022 №1
Maqola mavzusi
COMPARATIVE CHARACTERISTICS OF MORPHOMETRIC PARAMETERS OF KIDNEYS IN POLYPRAGMASIA WITH ANTI-INFLAMMATORY PREPARATIONS (63-73)
Mualliflar
MUSTAFOEV Zafar Mustafoevich TESHAEV Shukhrat Jumaevich
Muassasa
Samarkand State Medical Institute Buxoro State Medical Institute
Annotatsiya
Objective: To study morphometric changes in the structure of the kidneys of white rats with polypharmacy with anti-inflammatory drugs. Methods: The study was carried out on 50 male white rats, weighing from 210 to 320 g, kept in a vivarium with a standard diet, free access to water, and a normal lighting regime. The animals were divided into 3 groups. Results: When comparing the morphometric parameters of the rats of the 3rd group with those of the 2nd group, a significant decrease was found. The area of the renal corpuscle decreased 5.14%, 5.05%, 3.19% and 3.02%, the outer diameter of the proximal convoluted tubule decreased 8.13%, 6.11%, 4.08% and 3.42%, the diameter of the lumen of the tubule decreased by 6.33%, 5.09%, 3.12% and 3.08%, the outer diameter of the distal convoluted tubule decreased by 7.12%, 5.07%, 5.03% and 4.48%, the diameter of the lumen tubule decreased by 4.47%, 4.04%, 3.07% and 2.31%. Conclusions. The presence of the effect of polypharmacy by anti-inflammatory drugs on the kidneys indicates that polypharmacy has a detrimental effect on urinary excretion, reduces urinary excretion and has a sufficient level of risk for the body.
Kalit so'zlar
renal corpuscles, nephron, proximal convoluted tubule, distal convoluted tubule, polypharmacy.
Adabiyotlar
1. Биккинина Г. М., Сафуанов А. Р. Нежелательные лекарственные реакции нестероидных противовоспалительных препаратов // Молодой ученый. - 2015. - № 7 (87). - С. 269-272. 2. Бахронов.Ж.Ж. Буйрак тузилишининг морфофункционал хусусиятлари ва турли хил ташқи омиллар таъсирида ўзгариши. Доктор ахборотномаси. –Самарқанд, 2020, № 3.1 (96), 120-122 б. (14.01.00; № 35) 3. Jur'at J. Bakhronov, Shukhrat J. Teshaev, Musharraf S. Shodieva. Morphometric characteristics of parts of rat kidney nephron in normal and under the influence of an antiseptician - facility 2 roadtimulator on the background of chronic radiating disease. International Journal of Pharmaceutical Research, 2021, - Vol 13, Issue 1, - P. 683-686 (Scopus) 4. Конопля Е.Ф., Федосенко О.Л. Отдаленные эффекты внешнего облучения репродуктивной системы половозрелых крыс-самцов // Проблемы здоровья и экологии. - 2008. - № 18. - С. 117-119. 5. А.П.Бирюков. Злокачественные новообразование мочеполовой системы у облученного населения. -2001. №1 С.23. 6. Тешаев Ш.Ж., Хасанова Д.А. Сравнительная характеристика морфологических параметров лимфоидных структур тонкой кишки крыс до и после воздействия антисептика-стимулятора Дорогова фракции 2 на фоне хронической лучевой болезни // Оперативная хирургия и клиническая анатомия (Пироговский научный журнал) 2019, Том 3, №2, С.19-24. 7. Khasanova D.A., Teshaev Sh.J. Topografic-anatomical features of lymphoid structures of the small intestine of rats in norm and against the background of chronic radiation diseases- European science review № 9-10 2018, P. 197-198