Doktor axborotnomasi 2024, №4 (116)


Тема статьи

A MODERN VIEW OF ANEMIA IN CHILDREN WITH CHRONIC KIDNEY DISEASE (106-111)

Авторы

N. Sh. Ashurova, M. D. Muradova

Учреждение

Samarkand state medical university, Samarkand, Uzbekistan

Аннотация

Anemia is a common complication in children with chronic kidney disease (CKD). It significantly worsens the quality of life and affects the growth and development of the child. Understanding the mechanisms of anemia devel opment and its diagnosis is important for effective treatment. In this regard, anemia in children with CKD requires a comprehensive approach to diagnosis and treatment. Early diagnosis and adequate therapy can significantly improve the quality of life of children with this condition and contribute to their normal development.

Ключевые слова

anemia in chronic diseases, nephrogeni106c anemia, erythropoietin, sucrosomal iron.

Литературы

1. Markdante K., Kligman R. The basics of pediatrics by Nelson //Translated from English. EVA Kokareva. – 2021. – vol. 8. 2021; 612-26 2. Baranov I. I., Salnikova I. A., Nesterova L. A. Clinical recommendations for the diagnosis and treatment of iron deficiency conditions: a view from 2022 //Obstetrics and gynecology: News. Opinions. Training. – 2022. – T. 10. – №. 2 (36). – Pp. 56-64. 3. Smirnova N.N., Kuprienko N.B., Novikova V.P., Khavkin A.I. Iron metabolism in obesity in children and adoles cents //Questions of dietetics. – 2021. – vol. 11. – No. 1. – pp. 44-49. 4. Akhmedova E.A. Chronological relationship between children (literature review). //Housing and communal ser vices. Clinic for the prevention of tibbiet journal. – 2024. – Vol.1. – No. 1. – pp. 94-98. 5. Andrashi K. M. Working Group on improving global outcomes (KDIGO) in the field of CKD. The KDIGO 2012 Clinical Practice Guide for the assessment and management of chronic kidney disease //Kidney inter. – 2013. – vol. 84. – pp. 622-623. 6. Smirnov A.V., Shilov E.M., Dobronravov V.A. and others. National recommendations. Chronic kidney disease: basic principles of screening, diagnosis, approaches to prevention and treatment //Nephrology (St. Petersburg). – 2012. – Vol. 16. – No. 1. - pp. 89-115. 7. Mitznefes M. M. Cardiovascular complications of chronic kidney disease in children //Pediatric nephrology. - 2008. – Vol. 23. – No. 1. – pp. 27-39. 8. Tsygin A. N., Leumann E., Sarkisyan A. A. Pediatric nephrology: a practical guide //AN Tsygin, E. Loiman, AA Sarkisyan. M.: Litterra CJSC. – 2010. 9. Katie-Reddy S. R., Singh A. K. Target hemoglobin level in chronic kidney disease: a pediatric view //Pediatric nephrology. - 2009. – Vol. 24. – No. 3. – pp. 431-434. 10. De Benoit B., McLean E., Egli I., Cogswell M. The worldwide prevalence of anemia, the WHO information sys tem on vitamin and mineral nutrition, 1993-2005. //Nutrition in the public health system. - 2009. – vol. 12. – No. 4. – pp. 444-454. 11. Mitsnefes M. M., Kimball T. R., Kartal J., Witt S. A., Glascock B. J., Kuri P. R., Daniels S. R. Progression of left ventricular hypertrophy in children with early stage chronic kidney disease: a 2-year follow-up study // Journal of Pediatrics. - 2006. – Vol. 149. – No. 5. – pp. 671-675. 12. Tamura M., Wittinghoff E., Yang J., Go A. S., Seliger S. L., Kusek J. V., Jaffe K. Anemia and the risk of cognitive decline in chronic kidney disease // BMC nephrology. – 2016. – Vol. 17. – pp. 1-7. 13. Dalinghaus E. K., Noah A.M., Atkinson M. A., Fadrowski J. J. Hemoglobin level and risk of hospitalization and mortality in children on peritoneal dialysis //Pediatric nephrology. - 2014. – Vol. 29. – pp. 2387-2394. 14. Gerson A., Hwang W., Fiorenza J., Bart K., Kaskel F., Weiss L., Firth S. Anemia and health-related quality of life in adolescents with chronic kidney disease //American Journal of Kidney Diseases. - 2004. – vol. 44. – No. 6. – pp. 1017-1023. 15. Varadi B. A., Silverstein D. M. Treatment of anemia with drugs stimulating erythropoiesis in children with chronic kidney disease //Pediatric nephrology. - 2014. – Vol. 29. – pp. 1493-1505. 16. Vandevoorde R. G., Varadi B. A. Treatment of chronic kidney diseases //Pediatric nephrology. - 2009. – Vol. 2. – pp. 1660-1692. 17. Koshi S. M., Giri D. F. Anemia in children with chronic kidney disease //Pediatric nephrology. - 2008. – Vol. 23. – pp. 209-219. 18. Jeng S. S., Chen Y. H. The relationship of zinc with anemia // Nutrients. – 2022. – vol. 14. – No. 22. – p. 4918. 19. Atkinson M. A., Pierce K. B., Fadrowski J. J., Benador N. M., White K. T., Thurman M. A., Firth S. L. The rela tionship between common markers of iron storage and hemoglobin levels in children with chronic kidney dis ease //Pediatric nephrology. - 2012. – Vol. 27. – pp. 2275-2283. 20. Kuragano T., Okami S., Tanaka-Mizuno S., Uenaka H., Kimura T., Ishida Y., Hayasaki T. Treatment of anemia, hemoglobin variability and clinical manifestations in patients with chronic kidney disease who do not receive dial ysis in Japan //Kidney360. – 2023. – Article 10.34067. 21. Park K. H., Valor E. V., Waring A. J., Ganz T. Hepcidin is an antimicrobial peptide synthesized in the liver in urine //Journal of Biological Chemistry. - 2001. – Vol. 276. – No. 11. – Pp. 7806-7810. 22. Coin D. V. Hepsidin: clinical benefit as a diagnostic tool and therapeutic target //Kidney international. – 2011. – Vol. 80. – No. 3. – pp. 240-244. 23. Zaritsky J., Yang B., Wang H. J., Westerman M., Albina G., Nemeth E., Saluski I. B. Hepcidin is a potentially new biomarker of iron levels in chronic kidney disease //Clinical Journal of the American Society of Nephrology. – 2009. – Vol. 4. – No. 6. – pp. 1051-1056. 24. Kemna E., Pickers P., Nemeth E., van der Hoeven H., Swinkels D. Analysis of levels of hepcidin, serum iron and cytokines in blood plasma in people who were injected with LPS, over time time //Blood. – 2005. – Vol. 106. – No. 5. – pp. 1864-1866. 25. Malyshko Yu., Myslivets M. Hepsidin for anemia and inflammation in chronic kidney disease //Examination of kidneys and blood pressure. – 2007. – Vol. 30. – No. 1. – pp. 15-30. 26. Murkamilov, I. T., Aitbaev, K. A., Fomin, V. V., Murkamilova, Zh. A., Sabirov, I. S., Rayimzhanov, Z. R., Yusupov, F. A. Proinflammatory cytokines in patients with chronic kidney disease: Interleukin-6 is in focus // Archive of Internal Medicine. – 2019. – T. 9. – №. 6 (50). – Pp. 428-433. 27. Aitbaev, K. A., Murkamilov, I. T., Fomin, V. V., Murkamilova, Zh. A., Rayimzhanov, Z. R., Yusupov, F. A., & Aidarov, Z. A. Inflammation in chronic kidney disease: sources, consequences and anti-inflammatory therapy // Clinical medicine. – 2018. – vol. 96. – No. 4. – pp. 314-320. 28. Atkinson M. A., Firth S. L. Anemia in children with chronic kidney disease //Nature Reviews Nephrology. – 2011. – Vol. 7. – No. 11. – pp. 635-641. 29. Tarantino J. A new system for the delivery of iron supplements with high bioavailability //Nutrafoods. – 2013. – vol. 12. – pp. 71-8. 30. Campanella, M. P., Ebbli, A., Gaibazzi, D., Panunzio, V., Tomasini, A. Campanella M. P. et al. Correction to: Effectiveness and compliance of oral liposomal iron (Sideral Forte) treatment for iron deficiency anemia: a valid alternative to iv. Iron therapies [Electronic resource] //Published as part of the 3rd Mediterranean Multidisciplinary Course on Iron Anemia abstract book. – 2015. – vol. 8. – No. S1. 31. Stuklov N. I., Semenova E. N. Treatment of iron deficiency anemia. Which is more important, efficiency or porta bility? Is there an optimal solution? //Women's health. – 2013. – No. 7. – pp. 117-121. 32. Stuklov N. I. Iron deficiency syndromes in diseases of the gastrointestinal tract: treatment prospects //Clinical medicine. - 2016. – vol. 94. – No. 6. – pp. 410-418. 33. Pisani, A., Riccio, E., Sabbatini, M., Andreucci, M., Del Rio, A., Visciano, B Effect of oral liposomal iron versus intravenous iron for treatment of iron deficiency anaemia in CKD patients: a randomized trial //Nephrology dialy sis transplantation. – 2015. – Vol. 30. – No. 4. – pp. 645-652. 34. Tandoi F., Giacchetti, L., Plantulli, A., Agosti, M. Liposomal iron vs iron sulfate for prophylaxis of sideropenic anemia in infants of very low birth weight: preliminary assessment to 3 months of correct age //Abstr. of XVIII Congresso Nazionale della Societa Italiana di Neonatologia. —Roma. – 2012. 35. Pshenichnaya K. I., Kasatkina T. N. Effectiveness of treatment of early stage iron deficiency conditions in chil dren // Pediatrics. — 2016. — № 7 (4). — C. 128–131. 36. Zhukovskaya E. V., Anisimov V. N., Sidorenko L. V. Efficacy and safety of liposomal iron in the treatment of iron deficiency anemia in young children //Pediatric Bulletin of the Southern Urals. - 2017. – No. 2. – pp. 48-55. 37. Antoine E., Mehedintu, C., Mitran, M., & Diculescu, D. Sucrosomial® iron efficacy in recovering from mild and moderate iron-deficiency anemia in the postpartum period //BMC Pregnancy and Childhood. – 2023. – Vol. 23. – No. 1. – p. 360. 38. Bertani, L., Tricò, D., Zanzi, F., Baiano Svizzero, G., Coppini, F., de Bortoli, N., Marchi, S. Oral sucrosomial iron is as effective as intravenous ferric carboxy-maltose in treating anemia in patients with ulcerative colitis // Nutrients. – 2021. – T. 13. – No. 2. – pp. 608. 39. Pisani A., Riccio E., Sabbatini M., Andreucci M., Del Rio A. Visciano B. Effect of oral liposomal iron versus in travenous iron for treatment of iron deficiency anaemia in CKD patients: a randomized trial //Nephrology dialysis transplantation. – 2015. – vol. 30. – No. 4. – pp. 645-652. 40. Giordano, G., Mondello, P., Tambaro, R., De Maria, M., d'Amico, F., Sticca, G., & Di Falco, C. Giordano G. et al. 341 Intravenous iron support vs oral liposomal iron support in patients with refractory anemia treated with Epo alpha. Monocentric prospective study //Leukemia research. – 2011. – №. 35. – P. S137. 41. Mafodda A. Giuffrida, D., Prestifilippo, A., Azzarello, D., Giannicola, R., Mare, M., & Maisano, R. (2017) Oral sucrosomial iron versus intravenous iron in anemic cancer patients without iron deficiency receiving darbepoetin alfa: a pilot study //Supportive Care in Cancer. - 2017. – V. 25. – p. 2779-2786. 42. Minushkin O. N., Elizavetina G. A., Ivanova O. I. Some approaches to the treatment of iron deficiency anemia // Effective pharmacotherapy. – 2012. – No. 27. – pp. 34-39. 43. Ashurova, N.Sh. (2024). Dynamics of hemoregulation indices after treatment absolute anemia with chronic kidney disease in children. ISJ Theoretical & Applied Science, 10 (138), 151-156. 44. Ashurova N.Sh., Mukhamadiev N.Q. Assessment of Hemodynamic Parameters by Type of Anemia in Children with Chronic Kidney Disease // Central Asian Journal of Medical and Natural Science. 2024. Т. 5, №4. С. 230 238.