Биология ва тиббиёт муаммолари 2024 №5 (156)

Тема статьи

GENETIC MARKERS ASSOCIATED WITH VEGETATIVE DYSFUNCTIONS IN ATHLETES (329-332)

Авторы

Doniyorov Bakhriddin Bakhrom ugli, Mavlyanova Zilola Farhadovna, Djurabekova Aziza Tokhirova, Kim Olga Anatolevna, Shamsiddinova Madinabonu Shuxrat kizi

Учреждение

Samarkand State Medical University, Republic of Uzbekistan, Samarkand

Аннотация

The article presents analytical data on the study of the genetic aspects of catecholamine metabolism, which play a key role in understanding many physiological and psychological processes in the human body. It has been shown that one of the most important genes related to dopamine metabolism and its derivatives is the COMT (catechol-O-methyltransferase) gene. This gene encodes an enzyme involved in the metabolism of catecholamines, including dopamine, adrenaline, and norepinephrine, which play a crucial role in regulating many physiological processes, including stress response, mood regulation, and cardiovascular system dynamics. It has been determined that COMT gene polymorphisms exhibit significant variations across different populations worldwide and play an important role in shaping mental health and cognitive functions.

Ключевые слова

catecholamines, metabolism, COMT gene, vegetative dysfunction, cognitive functions, stress, cardiovascular system.

Литературы

1. Berridge, K. C., & Robinson, T. E. (1998). What is the role of dopamine in reward: hedonic impact, incentive salience, or both? Brain Research Reviews, 28(1), 307-369. 2. Cantoni, G. L. (1953). The biological methylation of nicotinamide // Journal of Biological Chemistry. – 204(1). - 403-416. 3. Chen, J. et al. (2016). The role of COMT in the metab-olism of catecholamines in humans // Psychoneuroendocrinology 4. Chen J., et al. (2004). "Functional significance of a genetic polymorphism in catechol-O-methyltransferase" // Cognitive Neuropsychiatry. - 9(4): 263-269. 5. Chen C., et al. (2004). Influence of COMT on the risk of schizophrenia: A case-control analysis in a Chinese population // American Journal of Psychiatry. - 161(10), 1867-1870. 6. Diatchenko, L., Nackley, A., & Tchivilev, I. (2006). "Human catechol-O-methyltransferase: a missing link between genetic variation and clinical pain" // Pain. -126(1-3), 167-179. 7. Domschke, K. et al. (2010). Genetic variation in the COMT gene as a predictor of anxiety levels in a healthy population // American Journal of Psychiatry 8. Ehlers, C. L., et al. (2021). Impact of COMT Variation on Stress Reactivity and the Autonomic Nervous System// Psychosomatic Medicine. - 83(5). - 443-450. 9. Ferreira, J. P., et al. (2018). COMT Val158Met Poly-morphism in Hypertension: A Review // Hypertension Re-search. - 42(10). - 1647-1658. 10. Garrison, J. L. et al. (2015). Functional characterization of a COMT polymorphism (Val158Met) on catecholamine metabolism // Journal of Neurochemistry 11. Gonzalez J.R., et al. (2011). Variation in the COMT gene and cognitive performance in genetic association studies // Behavioral Genetics. - 41(4). - 496-505. 12. Guldberg, H. C., & Laursen, H. (1968). Enzymicformation of homovanillic acid and other methoxycompounds in human liver. Acta Pharmacologica etToxicologica, 26(1), 101-110. 13. Hatzimanolis, A. et al. (2019). Stress resilience and genetic variations: The role of COMT and BDNF // Cogni-tive, Affective, & Behavioral Neuroscience 14. Johnson, M. P., & Ehlers, C. L. (2002). "Genetic varia-tion in the COMT gene and the response to stimulants" // Psychiatric Genetics. - 12(4), 225-234. 15. Kamilova R. T., Mavlyanova Z. F., Abdusamatova B. E. Evaluation of the impact of systematic volleyball on somatotypological characteristics of the body //Bulletin of the Kazakh National Medical University. – 2016. – №. 4. – С. 212-217. 16. Karyotakis, K. A., & Stamataki, E. (2018). The Role of COMT in Dopamine Metabolism and Medical Conditions // Journal of Neurochemistry. - 144(4), 493-504. 17. Kauffman, H. M., et al. (2022). An Overview of Cate-cholamine Regulation in Cardiovascular Disease // Ameri-can Journal of Cardiology. - 130(1). - 77-85. 18. Kaufman, S. (1962). The mechanism of the enzymatic conversion of tyrosine to 3,4-dihydroxyphenylalanine. Journal of Biological Chemistry. - 237(3), 708-713. 19. Kim O. A., Sharafova I. A., Baratova S. S. Migraine in athletes: features and methods of correction //Safe Sport-2016. – 2016. – С. 78-80. 20. Maxmudov S., Mavlyanova Z., Jumanov J. Analysis bioindustries indicators of body composition of individuals at a young age, not engaged in physical culture //InterConf.–2021. 21. Morkrid L., et al. (2010). "Association of COMT gene polymorphisms with blood pressure" // Journal of Human Hypertension. - 24(12): 761-767. 22. Munianga, S. B., & Correct, J. (2017). Role of the COMT Gene in Suicidal Behavior // Psychiatry Research. - 254, 103-108. 23. Nackley, A. G. et al. (2006). Functional analysis of a new allele of the COMT gene associated with a lower pain perception // Nature Genetics 24. Ntaios G., et al. (2010). "Catechol-O-methyltransferase (COMT) genotype and cardiovascular risk" // European Journal of Cardiovascular Prevention & Rehabilitation. - 17(3): 339-346. 25. Pomeranz, B., et al. (2017). Gender Differences in Heart Rate Variability: A Genetic Perspective // European Journal of Applied Physiology. - 117(3), 535-543. 26. Strickland, C. et al. (2013). The impact of Val158Met on cognition and brain structure: A meta-analysis // Neu-robiology of Learning and Memory 27. Tunbridge, E. M., et al. (2006). Catechol-O-Methyltransferase (COMT), Stress, and Cognitive Func-tion: A Review of the Literature // Frontiers in Integrative Neuroscience. - 1, Article 3. 28. Wise, R. A. (2004). Dopamine, learning, and motiva-tion. Nature Reviews Neuroscience, 5(6), 483-494. 29. Zha, S. et al. (2014). Distribution of COMT gene pol-ymorphisms and implications for health and disease // PLoS One 30. Zhang, Y., et al. (2020). The Role of COMT in Neuro-transmitter Regulation and Digestive System Disorders // Digestive Diseases and Sciences. - 65(11), 3192-3200. 31. Бурханова Г., Мавлянова З., Ким О. Влияние спортивного питания на физическое развитие детей и подростков с повышенной физической нагрузкой //Журнал проблемы биологии и медицины. – 2017. – №. 4 (97). – С. 24-26. 32. Баратова С., Ким О. А., Шарафова И. А. Особенности темперамента и его влияние на выбор вида спортивной деятельности //Безопасный спорт-2016. – 2016. – С. 16-18. 33. Баратова С. С., Мавлянова З. Ф., Шарафова И. А. Индивидуально-типологические особенности, обуславливающие выбор вида спортивной деятельности //Современные проблемы психологии и образования в контексте работы с различными категориями детей и молодежи. – 2016. – С. 190-191. 34. Камилова Р. Т. и др. Оценка влияния систематических занятий различными группами видов спорта на гармоничность физического развития организма юных спортсменов Узбекистана //Спортивная медицина: наука и практика. – 2017. – Т. 7. – №. 1. – С. 86-91. 35. Камилова Р. Т. и др. Сравнительная оценка показателей силовых индексов ведущей руки и спины среди детей Узбекистана, занимающихся различными группами видов спорта //Спортивная медицина: наука и практика. – 2017. – Т. 7. – №. 2. – С. 61-69. 36. Худойкулова Ф. В. и др. the structure, age features, and functions of hormones. pedagog, 1 (5), 681-688. – 2023. 37. Махмудов С. Динамика изменений тромбоцитарной активности у спортсменов-гребцов //Journal of Experimental Studies. – 2023. – Т. 1. – №. 7. – С. 22-27.