Биология ва тиббиёт муаммолари 2024 №2 (152)

Тема статьи

ОНА СУТИ ЦИТОКИН ВА ГОРМОНЛАРИНИНГ (ПРОЛАКТИН) ЯНГИ ТУҒИЛГАН ЧАҚАЛОҚНИНГ ИММУН ҲУЖАЙРАЛАРИ ФУНКЦИЯЛАРИГА ТАЪСИРИ (364-370)

Авторы

Хасанов Бахтиёр Буртханович

Учреждение

Бухоро давлат тиббиёт институти, Ўзбекистон Республикаси, Бухоро ш.

Аннотация

Она сутининг цитокинлари, ўсиш омиллари ва турли гормонлар иммунитет ҳужайраларининг кўпайиши, омон қолиши, дифференциацияси ва функциясини биргаликда бошқаради. Ушбу бирикмаларнинг кенг доираси инсон сутида мавжуд бўлиб, янги туғилган чақалоққа ичак билан боғланган ва периферик лимфоид тўқималарнинг тез ривожланиши ва етилиши даврида берилади. Янги туғилган чақалоқларга она сути таркибий қисмларининг кўпчилигининг кўрсатиладиган иммуномодуляцион функционал аҳамияти номаълум. Шу билан бирга, сут пролактинининг неонатал иммунитет тизимининг ривожланишининг регулятори бўлиб хизмат қилиши ҳақида далиллар мавжуд бўлиб, сутнинг иммуномодуляцион фаоллиги бўлган таркибий қисмлар неонатал иммунитетни ривожлантириш агенти бўлиб хизмат қилиши мумкин деган тахминни қўллаб-қувватлайди.

Ключевые слова

цитокинлар, пролактин, сут, иммун тизимининг ривожланиши.

Литературы

1. Азизова, Ф. Х., Юлдашева, М. Т., Тухтаев, К. Р., Сагдуллаев, Н. Х., & Худойбергенова, Ш. Ш. (2014). Структурные особенности тимуса при экспериментальном гипотиреозе у молодых крыс. Морфология, 145(3), 11-11a. 2. Зуфаров, К. А., Тухтаев, К. Р., & Хасанов, Б. Б. (2003). Количественные и ультраструктурные характеристики иммунокомпетентных клеток молочной железы в динамике беременности и лактации. Морфология, 124(4), 74-79. 3. Хасанов, Б. Б. (2022). Морфология молочной железы при беременности и лактации. Бухара. Типография" Sadriddin Salim Buxoriy" при Бухарском государственном университете, 120. 4. Хасанов, Б. Б. (2022). Иммуногенные свойства молочных желез и грудного молока. Re-health journal, (3 (15)), 21-30. 5. Хасанов, Б. Б. (2022). Структурно-функциональные особенности селезенки. Достижения науки и образования, (5 (85)), 66-73. 6. Хасанов, Б. Б. (2024). Клеточные компоненты секретов молочной железы и постнатальный иммунтет потомства. Re-health journal, (1 (21)), 64-79. 7. Хасанов, Б. Б. (2024). Влияние экстрагени-тальной патологии матери на гематологические показатели потомства в динамике раннего постнатального онтогенеза. Re-health journal, (1 (21)), 111-115. 8. Bakhtiyor Burtkhanovich Khasanov (2023). The influence of toxic hepatitis of the mother structural and functional relationships of immunocompetent breast cells of lactating rats and small intestines of rats during lactation. Journal of Korean Academy of Psychiatric and Mental Health Nursing, 5 (4), 26-32. 9. Bazan, J. F. (1989) A novel family of growth factor receptors: a common bind¬ing domain in the growth hormone, prolactin, erythropoetin and IL-6 receptors and the p75 IL-2 receptor b-chain. Biochem. Biophys. Research Comm. 164: 788-795. 10. Bernton, E., Meltzer, M. & Holaday, J. (1988) Suppression of macrophage acti¬vation and T-lymphocyte function in hypoprolactinemic mice. Science 239: 401 -407. 11. Chen, P., Smith, M.S. Regulation of Hypothalamic Neuropeptide Y Messenger Ribonucleic Acid Expression during Lactation: Role of Prolactin(Article)(Открытый доступ) // The Netherlands. Endocrinology, Volume 145, Issue 2, February 2004, Pages 823-829 12. Ellis, L. A., Mastro, A. M. & Picciano M. F. (1996) Milk-borne prolactin and neo¬natal development. J. Mammory Gland Biol. Neoplasia 1: 259 - 270. 13. Ellis, L. A. & Picciano M. F. (1992) Milk-borne hormones: regulators of devel¬opment in neonates. Nutr. Today 27: 6-14. 14. Ellis, L. A. & Picciano M. F. (1995) Bioactive and immunoreactive prolactin vari¬ants in human milk. Endocrinology 136: 2711 -2720. 15. Furdui, V., Leorda, A., & Balan, I. (2023). Особенности репродуктивной функции при вирусном гепатите и сахарном диабете: обзор. Sănătatea, medicina şi bioetica în societatea contemporană: studii inter şi pluridisciplinare: Materialele Conferinței Științifice Internaționale, ediția a VI-a, 6-7 octombrie 2023. 16. Gala, R. & Shevach, E. (1993) Influence of bromocriptine administration to mothers on the development of pup thymocyte and splenocyte subsets and on mitogen-induced proliferation in the mouse. Life Sci. 53: 1181 - 1994. 17. Goldman, A. S., Chheda S., Garafalo R. & Schmalsteig, F. C. (1996) Cytokines in human milk. Properties and potential effects upon the mammary gland and the neonate. J. Mammary Gland Biol. Neoplasia. 1: 251 - 258. 18. Goldman, A. S. & Goldblum, R. M. (1995) Defense agents in milk. In: Handbook of Milk Composition (Jensen, R. G., ed.), pp. 727 - 748. Academic Press, San Diego, CA. 19. Gonnella, P., Harnatz, P. & Walker, W. A. (1989) Prolactin is transported across the epithelium of the jejunum and ileum of the suckling rat. J. Cell Physiol. 140: 138-149. 20. Grove, D. S., Bour, B., Kacsoh, B. & Mastro, A. M. (1991) Effect of neonatal milk-prolactin deprivation on the ontogeny of the immune system. Endocr. Regul. 25: 111-119. 21. Gunes, H. & Mastro, A. M. (1996) Prolactin receptor gene expression in rat splenocytes and thymocytes from birth to adulthood. Mol. Cell. Endocrinol. 117: 41 -52. 22. Guy-Grand, D., Rocha, B. & Vassalli, P. (1993) Origin and development of gut intraepithelial lymphocytes. In: Advances in Host Defense Mechanisms (Gallin, J. I. & Faus, A. S., eds.) Vol. 9 23. Mucosal Immunology: Intraepithelial Lymphocytes (Kiyono, H. & McGhee J. R., eds.), pp. 21 -31. Raven Press, New York, NY. 24. Hoeffler, J. P., Boockfor, F. R. & Frawley, L. S. (1985) Ontogeny of prolactin cells in neonatal rats: initial prolactin secretors also release growth hormone. Endocrinology 117: 187 - 195. 25. Kacsoh, B., Veress, Z., Toth, B. E., Avery, L. M. & Grosvenor, C. E. (1993) Bioac¬tive and immunoreactive variants of prolactin in milk and serum of lactating rats and their pups. J. Endocrinol. 138: 243 - 257. 26. Khasanov, B. B. (2020). Experimental chronic toxic hepatitis and hematological features in the dynamics of mother's and the offspring lactation. European Journal of Molecular & Clinical Medicine, 7(09), 1367-1373. 27. Khasanov, B. B. (2021). Structural and functional features of immunocompetent breast cells glands during pregnancy and lactation in chronic hepatitis. Psychology and Education, 58(2), 8038-8045. 28. Khasanov, B. B., Azizova, F. K., Sobirova, D. R., Otajonova, A. N., & Azizova, P. K. (2022). Toxic hepatitis of the female and the structural and functional formation of the lean intestine of of the offspring in the period breastfeeding. 29. Khasanov, B. B. (2022). Experimental autoimmune enterocolitis and features of mother's fertility and development of offspring. New Day in Medicine, 40(2), 466-471. 30. Khasanov, B. B., Ilyasov, A. S., & Sultanova, D. B. (2023). Extragenital pathology of the mother and morphological features of the development of the spleen in the period of early postnatal ontogenesis. European Chemical Bulletin, 12(8), 8332-8341. 31. Khasanov, B. B., & Azimova, S. B. (2023). Еxtragenital pathology of the mother and morphological features of the development of the thymus in the period of early postnatal ontogenesis. European Chemical Bulletin, 12(8), 8322-8331. 32. Mastro, A. M., Gunes, H., Reed, A., Urtishzk, S. & Frankel, J. (1995) Prolactin receptor expression by lymphoid cells of neonatal rats: downregulation by milk ingestion. Presented at the Annual Meeting of the International Society for Research on Human Milk and Lactation, Tlaxcala, Mexico. 33. Mercado, M. & Baumann, G. (1994) A growth hormone/prolactin-binding pro¬tein in human milk. J. Clin. Endocrinol. Metab. 79: 1637 - 1641. 34. Middleton, P. & Bullock, W. (1984) Ontogeny of the T-cell mitogen response in Lewis rats: III. Juvenile adherent supressor cells block adult mitogen re-sponses. Cell. Immunol. 88: 421 - 435. 35. Murphy, W. J., Rui, H. & Longo D. L. (1995) Effects of growth hormone and prolactin: immune development and function. Life Sci. 57: 1 -14. 36. Nagano, M., Chastre, E., Choquet, A., Bara, J., Gespach, C. & Kelly, P. A. (1995) Expression of prolactin and growth hormone receptor genes and their iso-forms in the gastrointestinal tract. Am. J. Physiol. 268: G431 - G442. 37. Nehlesen-Cannarella, S. L. & Chang, L. (1992) Immunology and organ trans-plantation in the neonate and young infant. Pediatr. Transplant. 4: 179 - 191. 38. Ottaway, C. A., Cheng, H. P. & Bejerknes, M. L. (1987) Migration of individual lymphocytes into Peyer’s patches in vivo. In: Recent Advances In Mucosal Immunology (McGhee, J., Mestecky, J., Ogra, P. & Bienenstock, J., eds.), pp. 295 -303. Plenum Press, New York, NY. 39. Postel-Vinay, M. C., Belair, L., Kayser, C., Kelly, P. A. & Djiane, J. (1991) Identifi-cation of prolactin and growth hormone binding proteins in rabbit milk. Proc. Natl. Acad. Sci. U.S.A. 88: 6687-6690. 40. Reber, P. M. (1993) Prolactin and immunomodulation. Am. J. Med. 95: 637¬644. 41. Reichlin, S. (1993) Neuroendocrine-immune interactions. N. Engl. J. Med. 329: 1246-1252. 42. Russell, D. H., Mills, K. T., Talamantes, F. J. & Bern, H. A. (1988) Neonatal ad-ministration of prolactin antiserum alters the developmental pattern of T- and B-lymphocytes in the thymus and spleen of BALB/c female mice. Proc. Natl. Acad. Sci. U.S.A. 85: 7404-7407. 43. Shyr, S. W., Crowley, W. R. & Grosvenor, C. E. (1986) Effect of neonatal pro¬lactin deficiency on prepubertal tuberoinfundibular and tuberohypophyseal dopaminergic neuronal activity. Endocrinology 119: 1217 - 1221. 44. Stephens, S. (1991) Maturation of the immune system in breast fed and bottle fed infants. In: Nutrient Modulation of the Immune Response (Cunningham- Rundles, S., ed.), pp. 301 -318. Marcel Dekker, New York, NY. 45. Talbot, P. Lacasse. The effect of incomplete milking or nursing on milk production, blood metabolites, and immune functions of dairy cows //J. Dairy Sci., 95 (2012), pp. 6503-6512 46. Viselli, S. M., Stanek, E. M., Mukherjee, P., Hymer, W. C. & Mastro, A. M. (1991) Prolactin-induced mitogenesis of lymphocytes from ovariectomized rats. En-docrinology 129: 983-990. 47. Whitworth, N. S. & Grosvenor, C. E. (1978) Transfer of milk prolactin to the plasma of neonatal rats by intestinal absorption. J. Endocrinol. 79: 191 - 199. 48. Xanthou, M. (1993) The development of the immune system. In: Neonatal Haemotology and Immunology II (Xanthou, M., Bracci, R. & Prindull, G., eds.), pp. 113 - 122. Elsevier, Amsterdam, Cytokine 49. Yousef Rasmi, Ladan Jalali, Saliha Khalid at others The effects of prolactin on the immune system, its relationship with the severity of COVID-19, and its potential immunomodulatory therapeutic effect //Cytokine, Volume 169, September 2023, 156253