Biomeditsina va amaliyot jurnali, 2022 №6

Тема статьи

RISK FACTORS AND FEATURES OF CORONARY HEART DISEASE IN PATIENTS WITH RHEUMATOID ARTHRITIS (355-359)

Авторы

Tairova Zarangis, Shodikulova Gulandom

Учреждение

Samarkand State Medical University

Аннотация

Objective: Study risk factors and peculiarities of the course of coronary heart disease in patients with rheumatoid arthritis. Methods: 84 patients with a diagnosis of RA examined, according to the criteria of ACR, who treated in the Department of Cardiorheumatology of Samarkand City Medical Association for the period from 2020 to 2022. Results: The diagnosis of coronary heart disease (CHD) established in 32 patients (38%). Of these, 4 (12.5%) had a confirmed diagnosis of CHD diagnosed previously (before the debut of RA), with typical angina in 15 (46.8%) patients, ischemia without pain in 7 (25.4%), and rhythm disturbances in 9 (28.2%). Two (6.25%) patients with CHD had a history of myocardial infarction. Conclusions. CHD established in 38% of RA patients. Almost 30% of RA patients had cardiac rhythm disturbances and painless ischemia, which related to the constant intake of NSAIDs, which have analgesic effec

Ключевые слова

coronary heart disease, risk factors, autoimmune inflammation.

Литературы

Agca R., Heslinga S. C., Rollefstad S., Heslinga M., McInnes I. B., Peters M. J., Kvien T. K., Dougados M., Radner H., Atzeni F., Primdahl J., Södergren A., Wallberg Jonsson S., van Rompay J., Zabalan C., Pedersen T. R., Jacobsson L., de Vlam K., Gonzalez-Gay M. A., Semb A. G., Kitas G. D., Smulders Y. M., Szekanecz Z., Sattar N., Symmons D. P., Nurmohamed M. T. EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015/2016 update. Ann Rheum Dis, 2017, vol. 76, no. 1, pp. 17-28. doi:10.1136/annrheumdis-2016-209775. 3. Bernardes M., Vieira T. S., Martins M. J., Lucas R., Costa L., Pereira J. G., Ventura F., Martins E. Myocardial Perfusion in Rheumatoid Arthritis Patients: Associations with Traditional Risk Factors and Novel Biomarkers [electronic resource]. Biomed Res Int, 2017. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434312/ (accessed 25.09.2021). 4. Błyszczuk P., Szekanecz Z. Pathogenesis of ischaemic and non-ischaemic heart diseases in rheumatoid arthritis. RMD Open, 2020, vol. 6, no. 1, pp. e001032. doi: 10.1136/rmdopen-2019- 001032. 5. DeMizio D. J., Geraldino-Pardilla L. B. Autoimmunity and Inflammation Link to Cardiovascular Disease Risk in Rheumatoid Arthritis. Rheumatol Ther, 2020, vol. 7, no. 1, pp. 19-33. doi: 10.1007/s40744-019-00189-0 6. Lacaille D., Avina-Zubieta J. A., Sayre E. C., Abrahamowicz M. Improvement in 5-year mortality in incident rheumatoid arthritis compared with the general population-closing the mortality gap. Ann Rheum Dis, 2017, vol. 76, no. 6, pp. 1057-1063. doi:10.1136/annrheumdis- 2016-209562. 7. Lai C. H., Hsieh C. Y., Barnado A., Huang L. C., Chen S. C., Tsai L. M., Shyr Y., Li C. Y. Outcomes of acute cardiovascular events in rheumatoid arthritis and systemic lupus erythematosus: a population-based study. Rheumatology (Oxford), 2020, vol. 59, no. 6, pp. 1355-1363. doi: 10.1093/rheumatology/kez456. 8. Mal K., Kumar R., Mansoor F., Kaur N., Kumar A., Memon S., Rizwan A. Risk of Major Adverse Cardiovascular Events in Patients With Rheumatoid Arthritis. Cureus, 2020, vol. 12, no. 12, pp. e12246. doi: 10.7759/cureus.12246. 9. Provan S. A., Lillegraven S., Sexton J., Angel K., Austad C., Haavardsholm E. A., Kvien T. K., Uhlig T. Trends in all-cause and cardiovascular mortality in patients with incident rheumatoid arthritis: a 20-year follow-up matched case-cohort study. Rheumatology, 2020, vol. 59, no. 3, pp. 505–512. doi:10.1093/rheumatology/kez371. 10. Shodikulova G.Z., Tairova Z.K., Khasanov O.G. ASSESSMENT OF THE STATE OF THE CARDIOVASCULAR SYSTEM IN PATIENTS WITH RHEUMATOID ARTHRITIS. Journal of TMA Bulletin, 2022, issue 2, pp. 183-185. 11. Shodikulova G.Z. Shonazarova N.X FEATURES OF THYROID DISEASE IN PATIENTS WITH RHEUMATOID ARTHRITIS WITH CARDIOMETABOLIC SYNDROME. Journal of cardiorespiratory research. 2022, vol 3, issue 2, pp. 22-25. 12. Wang H., Li X., Gong G. Cardiovascular outcomes in patients with co-existing coronary artery disease and rheumatoid arthritis. Medicine (Baltimore), 2020, vol. 99, no. 14, pp. e19658. doi: 10.1097/MD.0000000000019658.