Biomeditsina va amaliyot jurnali, 2022 №6

Тема статьи

RESULTS OF DIAGNOSIS AND TARGETS THERAPY IN PATIENTS WITH COLORECTAL CANCER WITH LIVER METASTASIS (210-214)

Авторы

Niyozova X. Shakhnoza, Kamishov V. Sergey, Qobilov R. Odiljon

Учреждение

Republican Specialized Scientific and Practical medical center of oncology and radiology

Аннотация

Objective: to study the results of diagnosis and targeted therapy of patients with colorectal cancer (CRC) with liver metastases. Methods: The study included 75 patients with metastatic CRC, including 39 (52.0%) men and 36 (48.0%) women, with a mean age of 62.3±4.9 years, with histologically verified adenocarcinoma of the rectum and colon. intestines. Results: In the diagnosis of liver metastases, ultrasound methods were used, including transrectal sonography, as well as computed tomography (CT). The most common were multiple liver metastases (92.0%), followed by bilobar metastases (81.3%). Monolobular metastases were diagnosed in 14.7% of patients, single - in 10.7% of patients and solitary - in 2.7% of patients with CRC. In the treatment of CRC patients with initially resectable liver metastases, the inclusion of targeted drugs in traditional chemotherapy regimens significantly improved the effectiveness of treatment for this category of patients. Conclusions: The combination of ultrasound with CT allows the most accurate determination of the characteristics of liver metastases in patients with colorectal cancer. It was shown that the best results of preoperative chemotherapy were shown by the XELOX/FOLFOX4 regimen, which includes the use of the targeted drug bevacizumab.

Ключевые слова

colorectal cancer, computed tomography, metastases, targeted drugs, ultrasound

Литературы

Ассесорова Ю.Ю., Киреев Г.В., Баленков О.Ю. Важнейшие современные тенденции онкологической заболеваемости в различных странах (обзор). Журнал теоретической и клинической медицины. 2009. №2. С.77-81. 2. Ибрагимов Ж.М., Туйджанова Х.Х., Ниёзова Ш.Х., Норбекова М.Х., Израильбекова К.Ш., Абдурахманов Д.А., Алимова С.С. Cовременные аспекты коррекции гепатотоксичности, индуцированной противоопухолевой химиотерапией. 2019. Colloquium-journal. №18-1. С.79-83. 3. Камышов С.В., Пулатов Д.А., Юлдашева Н.Ш. Изучение роли экстракорпоральной иммунофармакотерапии в снижении токсических эффектов химиолучевой терапии у пациентов с раком шейки матки. Евразийский онкологический журнал. 2015. Т.7. №4. С.28-34. 4. Камышов С.В. Современная иммунофармакотерапия в комплексном лечении рака шейки матки. Вестник науки и образования. 2018. №6 (42). Т.2. С.57-61. doi: 10.20861/2304- 2338-2018-127-007 5. Пророков В.В., Власов О.А., Тупицын Н.Н. Современное состояние проблемы лечения и прогноза колоректального рака // Вопросы онкологии. 2014. Т.60. №2 (114). С.28-33. 6. Jauhri M., Bhatnagar A., Gupta S., et al. Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing. Med Oncol. 2016;33(10):106. doi: 10.1007/s12032-016-0820-2 PMID: 27568332 7. Modest D.P., Martens U.M., Riera-Knorrenschild J., et al. FOLFOXIRI Plus Panitumumab As First-Line Treatment of RAS Wild-Type Metastatic Colorectal Cancer: The Randomized, Open-Label, Phase II VOLFI Study (AIO KRK0109). J Clin Oncol. 2019;37(35):3401-3411. doi: 10.1200/JCO.19.01340. 8. Paul R., David R.F., Radek L. et al. Time course of safety and efficacy of aflibercept in combination with FOLFIRI in patients with metastatic colorectal cancer who progressed on previous oxaliplatin-based therapy. European Journal of Cancer. 2015;51:18-26. 9. ТУРСУНОВ О. М. и др. интервенционные чрескожные технологии в лечении больных с синдромом механической желтухи //Журнал биомедицины и практики. – 2022. – Т. 7. – №. 1. 10. Yunusova L. et al. Sonography and magnetic resonance tomography in monitoring of recurrent cysts lesions of the neck //Annals of Cancer Research and Therapy. – 2021. – Т. 29. – №. 2. – С. 131-134. 11. Yunusova L. et al. Magnetic resonance imaging in the diagnosis of cystic lesions of the neck //Annals of Cancer Research and Therapy. – 2021. – Т. 29. – №. 1. – С. 102-109. 12. Rizaev J. A., Maeda H., Khramova N. V. Plastic surgery for the defects in maxillofacial region after surgical resection of benign tumors //Annals of Cancer Research and Therapy. – 2019. – Т. 27. – №. 1. – С. 22-23. 13. Rizaev Jasur, Norbutayev Alisher, Murtazayev Alisher. Modern methods for detecting oral cavity defects in hemoblastosis, detecting the degree of damage and prediction of the clinical current. Journal of Biomedicine and Practice. 2021, vol. 6, issue 5, pp. 45-51