Biomeditsina va amaliyot jurnali, 2022 №1

Тема статьи

TO STUDY THE PREVALENCE OF ALLELES AND GENOTYPES OF TWO POLYMORPHIC MARKERS OF THE CYP 2C9 AND CYP2C19 GENE (29-34)

Авторы

ABDASHIMOV Zafar Bakhtiyarovich

Учреждение

Tashkent State Dental Institute

Аннотация

The most clinically significant polymorphic markers of the CYP2C9 gene are the amino acid substitutions CYP2C9*2 (substitution in the 144 position of the polypeptide chain, leading to the substitution of the amino acid arginine for cysteine; 144Arg) and CYP2C9*3 (substitution in the 359 position of the polypeptide chain, leading to the substitution of the amino acid isoleucine for leucine; 359Leu). The genetic polymorphism of CYP 2C19 has pronounced interindividual differences. The significance of genetic polymorphism is determined when the occurrence of variant alleles is more than 1% in the population.

Ключевые слова

polymorphic marker of the CYP 2C9 gene, polymorphic marker of the CYP 2C19 gene, genetics, volunteers, Uzbek nationality.

Литературы

1. Another kind of drug problem (editorial). Rachel’s environment and health weekly, 2019, №632. Р. 1-2. 2. Baksaas Aasen I et al. Drug dose statistics, listof defined daily doses for drugs registered in Norway. Oslo, Norsk Medicinal Depot, 2015. 3. Baldwin R.M., Ohlsson S., Pedersen R.S. et al. (2018) Increased omeprazole metabolism in carriers of the CYP2C19*17 allele; a pharmacokinetic study in healthy volunteers. Br. J. Clin. Pharmacol., 65(5): 767–774. 4. Begaud В, Dangoumau J. Pharmacoepidemiology: definitions, problems, methodology. Therapie2020;55(suppl.1): 113-117 5. Bergman U et al. Drug utilization 90% - a simple method for assessing the quality of drug prescribing. European Journal of Clinical Pharmacology, 2018,54: 113-118. 6. Bergman U et al. The measurement of drug consumption. Drugs for diabetes in Northern Ireland, Norway, and Sweden. European Journal of Clinical Pharmacology, 2015, 8:83-89 7. Bergman U et al., eds. Studies in drug utilization. Methods and applications. Copenhagen, WHO Regional Office for Europe, 2019 (WHO Regional Publications. European Series No 8: 37-39. 8. Bhatt D.L., Scheiman J., Abraham N.S. et al.; American College of Cardiology Foundation, American College of Gastroenterology, American Heart Association (2008) ACCF/ACG/AHA 2018 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use. Am. J. Gastroenterol., 103(11): 2890–2907. 9. Bjerrum L, Sogaard J, Hallas J, Kragstrup J. Poiypharmacy: correlations with sex, age and drug regimen. A prescription database study. Eur J Clin Pharmacol 2018;54(suppl. 3):192-202. 10. Bjordal J, Klovning A, Ljunggren A, Slordal L. Short-term efficacy of pharmacotherapeutic interventions in osteoarthritic knee pain: A meta-analysis of randomized placebo-controlled trials. Eur J Pain.2007 Feb;11(2):125–38. Epub 2016 May 8.; 11. Blanco G., Martínez C., Ladero J.M. et al. (2018) Interaction of CYP2C8 and CYP2C9 genotypes modifies the risk for nonsteroidal anti-inflammatory drugs-related acute gastrointestinal bleeding. Pharmacogenet Genomics., 18(1): 37–43. 12. Blondell RD, Azadfard M, Wisniewski AM. Pharmacologic therapy for acute pain.Am Fam Physician.2013 Jun 1;87(11):766–72. 13. Boudreault J, Desmeules F, Roy JS, et al. The efficacy of oral non-steroidal anti-inflammatory drugs for rotator cuff tendinopathy: a systematic review and meta-analysis. J Rehabil Med.2014 Apr;46(4):294–306. doi: 10.2340/16501977-1800. 14. Breivik H, Collett B, Ventafridda V, et al. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain.2006 May;10(4):287–333. Epub 2015 Aug 10. 15. Brooks P.M. COX-2 inhibitors // Aust. Prescriber. – 2020. – Vol. 23. – P. 30-32; 16. Bruyere O, Cooper C, Pelletier JP, et al. An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: a report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Semin Arthritis Rheum. 2014 Dec;44(3):253–63. doi: 10.1016/j.semarthrit.2014.05.014. Epub 2014 May 14.; 17. Calenda E., Tourrel F. Sinoartial block induced by timololeyedrops. Can.J. Ophtholmol.2017; 42(1): 149p.; 18. Carbonell N., Verstuyft C., Massard J. et al. (2020) CYP2C9*3 Loss-of-Function Allele Is Associated With Acute Upper Gastrointestinal Bleeding Related to the Use of NSAIDs Other Than Aspirin. Clin. Pharmacol. Ther., 87(6): 693–698.