Biomeditsina va amaliyot jurnali, 2022 №2

Тема статьи

MEDICAL AND GENETIC PROPERTIES OF ADVERSE DRUG REACTIONS WHEN RECOMMENDING NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (23-28)

Авторы

DAMINOVA Lola Turgunpulatovna ABDASHIMOV Zafar Bakhtiarovich

Учреждение

Tashkent State Dental Institute

Аннотация

ANNOTATION Medicine at the present stage does not stand still, its progress leads to the concretization of methodological approaches. Currently, pharmacological science does not stand still, new medicines (drugs) are appearing and their number is increasing, approaches to their use are becoming more complicated. Currently developed drugs have a narrow direction, i.e. they are specific. Everyone knows that the processes of pharmacokinetics are genetically controlled, and drugs are mostly perceived by the body as xenobiotics. This work is relevant and requires in-depth study today.

Ключевые слова

Keywords: MDR1 genome, CYP2C19, cytochrome P450 enzymes, NSADs

Литературы

1. Alekseev V. V. Modern ideas and basic principles of pain therapy // Russian Medical Journal.- 2011.- No. 1.- Special issue.- pp. 6-11. 2. Bikkinina, G. M. Undesirable drug reactions of nonsteroidal anti-inflammatory drugs / G. M. Bikkinina, A. R. Safuanov. - Text : direct // Young scientist. — 2015. — № 7 (87). — Pp. 269- 272.— URL: https://moluch.ru/archive/87/16884 3. Zhuravleva M.V., Kukes V.G., Prokofiev A.B., Serebrova S.Yu., Gorodetskaya G.I., Berdnikova N.G. Rational use of NSAIDs - balance of effectiveness and safety (literature review) // International Journal of Applied and Fundamental Research. - 2016. - № 6-4. - pp. 687-696 4. 4. Klaritskaya I.L., Rabodyagova Yu.S. Polymorphism of the CYP2C19 gene and the clinical significance of its determination. Crimean Therapeutic Journal 2013;1:19-25. 5. Kukes V.G., Grachev S.V., Sychev D.A., Ramenskaya G.V. Drug metabolism: scientific foundations of personalized medicine. M.- GEOTAR-Media, 2008. 304 p. 6. Tashenova A.I. Glycoprotein-P transport system and pharmacokinetics of drugs. Biomedicine. 2010; 4: 24–32. 7. Yakusheva E.N., Chernykh I.V., Shchulkin A.V., Popova N.M. Glycoprotein - P: structure, physiological role and molecular mechanisms of functional activity modulation. Successes of physiological sciences. 2014; 45 (4): 90–98. 8. Bhala N, Emberson J, Merhi A, et al. Vascular and upper gastrointestinal effects of non- steroidal anti-inflammatory drugs: metaanalyses of individual participant data from randomised trials. Lancet. 2013 Aug 31;382 (9894):769–79. DOI: 10.1016/S0140–6736(13)60900–9. Epub 2013 May 30 9. Blondell RD, Azadfard M, Wisniewski AM. Pharmacologic therapy for acute pain. Am Fam Physician. 2013 Jun 1;87 (11):766–72. 11. 10. Crofford LJ. Use of NSAIDs in treating patients with arthritis. Arthritis Res Ther. 2013;15 Suppl 3:S2. DOI: 10.1186/ar4174. Epub 2013 Jul 24. 12. 11. Li Y.H., Wang Y.H., Li Y, Yang L. MDR1 gene polymorphisms and clinical relevance//Yi Chuan Xue Bao. 2006, Feb. Vol.33, №2. P. 93104. 12. Preissner SC, Hoffmann MF, Preissner R Polymorphic cytochrome P450 enzymes (CYPs) and their role in personalized therapy // PLoS One 2013;8(12): e82562. 13. Yiannakopoulou E. Pharmacogenomics of ace-tylsalicylic acid and other nonsteroidal antiinflammatory agents: clinical implications. Eur J Clin Pharmacol. 2013; 69: 1369-73.