Biomeditsina va amaliyot jurnali, 2022 №6

Тема статьи

THE SIGNIFICANCE OF THE G681A ALLELIC POLYMORPHISM OF THE CYP2C19 GENE IN THE GENESIS OF MALE FERTILITY DISORDERS (25-31)

Авторы

Irgashev S. Dilmurad, Gasanova S. Shakhina, Boboev T. Kodirjon

Учреждение

RSSPMCH MoH RUz

Аннотация

The role of the G681A polymorphism of the CYP2C19 gene in the formation of male infertility was analyzed. The study was conducted on a sample of 140 patients with various clinical forms of male infertility and 155 conditionally healthy fertile men. Despite the involvement of this locus in the regulation of the synthesis of sex hormones, especially androgens, the carriage of an unfavorable variant of this gene does not have an independent phenotypic effect on male fertility disorders, which allows us to conclude that this gene does not play an independent role in the genesis of male fertility disorders

Ключевые слова

male infertility, G681A polymorphism of the CYP2C19 gene, allele, genotype

Литературы

Fu L, Xiong DK, Ding XP, Li C, Zhang LY, Ding M, Nie SS, Quan Q. Genetic screening for chromosomal abnormalities and Y chromosome microdeletions in Chinese infertile men. J Assist Reprod Genet. 2012 Jun;29(6):521-7. 3. Liu XG, Hu HY, Guo YH, Sun YP. Correlation between Y chromosome microdeletion and male infertility. Genet Mol Res 2016;15(2):gmr.15028426. 4. 4.Colaco S, Modi D. Genetics of the human Y chromosome and its association with male infertility. Reprod Biol Endocrinol 2018; 16(1):14. 5. Krausz C, Riera-Escamilla A. Genetics of male infertility. Nat Rev Urol 2018; 15(6):369-84. doi: 10.1038/s41585-018-0003-3. 6. N. T. Trang and V. T. Huyen. Polymorphism of Xenobiotic Detoxification Genes and Male Infertility. Published: November 5th, 2018, DOI: 10.5772/intechopen.79233 7. Fang J, Wang S, Wang H, Zhang S, Su S, Song Z, Deng Y, Qian J, Gu J, Liu B, Cao J, Wang Z. The Cytochrome P4501A1 gene polymorphisms and idiopathic male infertility risk: a metaanalysis. Gene. 2014 Feb 10;535(2):93-6. doi: 10.1016/j.gene.2013.11.011. Epub 2013 Dec 6. PMID: 24316127. 8. Wang T, Hu T, Zhen J, Zhang L, Zhang Z. Association of MTHFR, NFKB1, NFKBIA, DAZL and CYP1A1 gene polymorphisms with risk of idiopathic male infertility in a Han Chinese population. Int J Clin Exp Pathol. 2017 Jul 1;10(7):7640-7649. 9. Carreau S, Lambard S, Delalande C, Denis-Galeraud I, Bilinska B, Bourguiba S. Aromatase expression and role of estrogens in male gonad : a review. Reprod Biol Endocrinol. 2003 Apr 11;1:35. 10. Carreau S, Levallet J. Cytochrome P450 aromatase in male germ cells. Folia Histochem Cytobiol. 1997;35(4):195-202. PMID: 9619418. 11. Исхакова Г.М., Измайлова С.М., Измайлов А.А. Генетические аспекты мужского бесплодия // Современные проблемы науки и образования. – 2015. – № 3 12. Яглова Н.В., Яглов В.В. Эндокринные дизрапторы - новое направление исследований в эндокринологии // Вестник РАМН. - 2012. - №3. - С. 56-61. 13. Yusupov Mashrab, Rizaev Zhasur, Ziyadullaev Shuxrat. The value of cytokines in children with escherichiosis. Journal of Biomedicine and Practice. 2022, vol. 7, issue 4, pp.58-63 14. Ziyadullaev S. K. et al. MARKER TNFα-308G/A IN PATIENTS WITH RELATIVE BLADDER CANCER //Oriental renaissance: Innovative, educational, natural and social sciences. – 2021. – Т. 1. – №. 8. – С. 926-932.