Gepato-gastroenterologik tadqiqotlar jurnali 2021, № 4

Тема статьи

COMPREHENSIVE TREATMENT OF BRONCHIAL ASTHMA IN CHILDREN USING RESISTOL (130-133)

Авторы

Sanakulov A.B., Mirzaeva Z.U.

Учреждение

Samarkand State Medical Institute

Аннотация

Studied 78 children with varying degrees of bronchial asthma severity at the clinic of Hospital, Outpatient and Emergency Therapy Department of Andijan State Medical Institute in Andijan, aged 6-14 years. For prospective study we have formed two groups of patients: the first group of patients who received standard baseline therapy and placebo tablet (n = 35); the second group of patients (n = 43), who received along with baseline therapy, received the drug "Resistol". Administration of this drug suppresses the metabolism of corticoid hormones in the body, and the duration of their action increases. Our own studies have shown that in Group 1 we managed to reduce the dose of inhaled glucocorticosteroids by 13.5 ± 3.1%. A particularly valuable effect of impaired β2-adrenoreceptor sensitivity due to excessive use of salbutamol. The positive effect of the drug was a decrease in the number of daytime and nighttime attacks, an increase in absolute PSV values and a decrease in pronounced variability. ICC values were normalized more effectively in most patients. Thus, treatment with the drug "Resistola" not only contributed to more effective rehabilitation of children with bronchial asthma, including increased parameters of external respiratory function, but also had a favorable effect on the condition of the upper airways, contributing, apparently, to a decrease in the severity of allergic inflammation.

Ключевые слова

Key words: bronchial asthma in children, immunology, resistol

Литературы

. Azizova ND, Shamsiyev FM, Akbarova N.Ya. / Interrelation of bronchial asthma and components of the metabolic syndrome. / / Tashkent. Pediatrics.-2012.-№3.-p.97-99. 2. Berestetsky AB, Leshchenko I.V., Beltyukov E.K., Popova S.D., Kardashina I.A. Differences in the properties of blood eosinophils in patients with bronchial asthma, atopic dermatitis and opisthorchiasis // Pulmonology.-2015-№4-С.34-42 3. Mizernitsky Yu.L., Tsaregorodtsev AD (Ed.) Pulmonology of childhood: problems and solutions. M .: 2012. - Vol.5. - 356 s. 4. Nisheva E.C. Inhaled glucocorticoids. // С-П. - 2011. - 43 p. 5.Skuchalina L.N. Bronchial asthma in children: clinical and epidemiological characteristics, optimization of diagnosis and treatment. / Abstract. Dr. honey. Of science 14.00.36.// Astana. - 2005. - 55 p. 6. Shamsiev FM, Khaydarova M.Sh., Mavlonova Sh.S. / Features of autonomic disorders in children with asthma. / / Tashkent. Pediatrics.-2015.-№3.-p.134-136. 7. Didonato A.J. Saatciogly F., Karin M. Molecular mechanisms of glucocorticoids. // Am. J. Resper. Crit Care Med. - 2012 - Vol. 150 8. Is the pharmacology of corticosteroids in the lung modified by age? // Med. J Aust.- 2015 / Jul. four; 183 (1 Suppl): S. 47-8 ’’ 9. Kelly-Pieper K, Patil SP, Busse P, Yang N, Sampson H, Li XM, Wisnivesky JP, Kattan M. Herbal Formula (ASHMI): a randomized, double-blinded, placebo-controlled, dose-escalation phase I study// J Altern Complement Med. 2014 Jul; 15 (7): 735.