Gepato-gastroenterologik tadqiqotlar jurnali 2021, № 4

Тема статьи

CLINICAL AND EPIDEMIOLOGICAL FEATURES IN PEDIATRIC PATIENTS IN WITH SARS-COV-2 INFECTION IN THE RYAZAN REGION (81-87)

Авторы

Belykh N.A. , Nataliya A. Anikeeva, Anastasia Yu. Panferuhina, Inna V. Piznjur

Учреждение

Ryazan State Medical University named after acad. I.P. Pavlov

Аннотация

To study the clinical and laboratory features of the course of SARS-CoV-2 infection (COVID-19) in children of the Ryazan region. A retrospective study carried out with the participation of 55 children hospitalized at the City Clinical Hospital No. 11 (Ryazan) from April 2020 to March 2021 with a diagnosis of new coronavirus infection COVID-19. Among those hospitalized, there was a predominance of children over the age of 12 years (61.8%). Almost one third of patients had comorbid pathology. The most common comorbidities were obesity, CVS and CNS pathology. More than half of the hospitalized children (58.2%) had intrafamilial contact with laboratory-confirmed cases of COVID-19. The main clinical manifestations in the observed children were: symptoms of intoxication, respiratory tract lesions and gastrointestinal symptoms. In the dominant number of cases (63.6%), lung damage corresponded to mild (CT-1) severity. More than half of the children (63.6%) had a concomitant bacterial infection. IgM antibodies to Mycoplasma pneumoniae were detected by ELISA in 15 patients (27.3%). A direct correlation was found between the degree of lung damage and the level of CRP (r = 0.31, p = 0.019), ALT (r = 0.30, p = 0.05) and LDH (r=0.27, p = 0.05), as well as the presence of concomitant diseases (r = 0.41, p = 0.002). Against the background of the therapy, positive dynamics was noted in the condition of all patients. Lethal outcomes not recorded in the studied sample of patients. Almost half of the patients (40%) had a comorbid pathology. The presence of concomitant bacterial infection was detected in 63.6% of children. Most patients are diagnosed with respiratory mycoplasmosis. A significant positive correlation was established between the degree of damage to the lung tissue and the presence of concomitant diseases, as well as deviations from the norm of a number of laboratory parameters (CRP, ALT, LDH). With timely treatment, most patients with viral lung disease caused by the new coronavirus infection COVID-19 had a favorable outcome of the disease.

Ключевые слова

Key words: new coronavirus infection, viral lung disease, community-acquired pneumonia,

Литературы

1. Митьковская Н.П., Карпов И.А., Арутюнов Г.П. [и др.]. Коронавирусная инфекция COVID-19 (обзор международных научных данных) // Неотложная кардиология и кардиоваскулярные риски. 2020. Т. 4, № 1. С. 784–815. [Mit'kovskaja NP, Karpov IA, Arutjunov GP, et al. Coronavirus infection COVID-19 (review of international scientific evidence). Neotlozhnaja kardiologija i kardiovaskuljarnye riski. 2020; 4 (1): 784–815]. In Russain 2. WHO Director-General's opening remarks at the media briefing on COVID-19 - 11 March 2020. URL: https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020 3. COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU). URL: https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6 4. Временные методические рекомендации «Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19)». Версия 11 (07.05.2021) / Министерство здравоохранения Российской Федерации. Москва, 2021. [Temporary guidelines "Prevention, diagnosis and treatment of new coronavirus infection (COVID-19)" Version 11 (05/07/2021) / Ministry of Health of the Russian Federation. Moscow; 2021]. In Russain 5. Children and COVID-19: state data report from the AAP and the children’s Hospital association. Version: 9/2/21. URL: https://www.aap.org 6. Screening and severity of coronavirus disease 2019 (COVID-19) in children in Madrid, Spain. JAMA pediatrics. 2020; Apr 8: e201346. doi: 10.1001/jamapediatrics.2020.1346. 7. Краснова Е.И., Карпович Г.С., Комиссарова Т.В. [и др.]. Особенности течения COVID-19 у детей различных возрастных групп // Педиатрия им. Г.Н. Сперанского. 2020. Т. 99, № 6. С. 141–147. [Krasnova EI, Karpovich GS, Komissarova TV, et al. Features of the course of COVID-19 in children of different age groups. Pediatrija im. G.N. Speranskogo. 2020; 99 (6): 141–147]. In Russain 8. Otto WR, Geoghegan S, Posch LC, et al. The Epidemiology of Severe Acute Respiratory Syndrome Coronavirus 2 in a Pediatric Healthcare Network in the United States. J Pediatric Infect Dis Soc. 2020; 9(5):523-529. doi: 10.1093/jpids/piaa074. PMID: 32559282; PMCID: PMC7337783. 9. Jahangir M, Nawaz M, Nanjiani D, et al. Clinical manifestations and outcomes of COVID-19 in the paediatric population: a systematic review. Hong Kong Med J. 2021;27(1):35-45. doi: 10.12809/hkmj208646. Epub 2020 Sep 30. PMID: 32994372. 10. Sanna G, Serrau G, Bassareo PP, et al. Children’s heart and COVID-19: up-to-date evidence in the form of a systematic review. Eur J Pediatr. 2020;179:1079–87. 11. Jutzeler CR, Bourguignon L, Weis CV. Comorbidities, clinical signs and symptoms, laboratory findings, imaging features, treatment strategies, and outcomes in adult and pediatric patients with COVID-19: A systematic review and meta-analysis. Travel Medicine and Infectious Disease. 2020; 37: 101825. Available at: https://doi.org/10.1016/j.tmaid.2020.101825