Biomeditsina va amaliyot jurnali, 2022 №3

Тема статьи

PREVALENCE OF ALLELES AND GENOTYPES OF TWO CYTOCHROME P450 HEPATIC SYSTEM ISOENZYMES (CYP2C19 and CYP2C9) AND THE MDR1 GENE AMONG HEALTHY VOLUNTEERS OF UZBEK NATIONALITY (123-129)

Авторы

DAMINOVA Lola Turgunpulatovna, ABDASHIMOV Zafar Bakhtiyarovich

Учреждение

SamDTU

Аннотация

The most clinically significant polymorphic markers of the CYP2C9 gene are the amino acid substitutions CYP2C9*2 (substitution in the 144 position of the polypeptide chain, leading to the substitution of the amino acid arginine for cysteine; 144Arg) and CYP2C9*3 (substitution in the 359 position of the polypeptide chain, leading to the substitution of the amino acid isoleucine for leucine; 359Leu). Nonsteroidal anti-inflammatory drugs (NSAIDs) are a group of widely used drugs. An important problem when taking NSAIDs are adverse drug reactions from the gastrointestinal tract at various levels - from dyspepsia to life-threatening complications such as bleeding or wound perforation. The formation of the risk of adverse drug reactions can be attributed to genetic factors, in particular, the polymorphism of the CYP2C9 gene. It has been shown that carriers of the "slow" alleles of the CYP2C9 gene (*2, *3) are more likely to develop gastric bleeding when taking NSAIDs (selecoxib, diclofenac, ibuprofen, naproxen or piroxicam)

Ключевые слова

alleles, genotypes, isoenzymes, volunteers, Uzbek nationality

Литературы

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