Biomeditsina va amaliyot jurnali, 2022 №3

Тема статьи

RARE CASE OF CERDJA-STRAUSS SYNDROME (107-112)

Авторы

ABDIYEV Kattabek Makhmatovich

Учреждение

SamDTU

Аннотация

Maqsad: katta yoshli bemorladda kam uchraydigan Cherdja-Stross sindromi ва tashhisi aniqlash. Material va Metodlar: Ushbu holat juda kam uchraydigan kasallik - allergik granulomatozli ChеrgeStross angeiiti 64 yoshli bemorda tashxis qo'yilgan bo'lsa-da, aksariyat hollarda bu vaskulit 35 yoshgacha bemorlarda uchraydi. Kasallikning gematologik ko'rinishi qondagi yuqori eozinofiliya bo’lib, tashxisning birinchi bosqichida sternal punktsiya va parazitologik tekshiruv asosida qo’yildi. Natijalar: Klinik ko'rinishda birinchi o'rinda jiddiy nevrologik simptomlar paydo bo'lishiga qaramay, shifokor tizimli vaskulyitni tashxislash uchun kerakli tekshiruvlar o'tkazganligi sababli o'z vaqtida tashxis qo'yish imkonini berdi. Xulosa. Bemorga o’tkazilgan davolash natijasida biroz ijobiy dinamika qayd etildi. Tavsiya etilgan: prednizolon 60 mg sxema bo’yicha 2 hafta davomida, so'ngra har haftada 5 mgdan qo’llab quvvatlovchi dozagacha kamaytirish – kuniga 0,2 mg/kg tana vazniga (ijobiy dinamikada – yil davomida), simptomatik terapiya; tsitostatik terapiya: siklofosfan 200 mg m/o har 2 kunda 1 mahal 2 hafta davomida, keyin 200 mg m/o har haftada 2 marta 3 oy davomida (yoki kuniga 2 mg/kg per os 14 kungacha), keyin qonda leykotsitlar nazorati ostida dozani kamaytirish – 1 haftada bir marta 1 oy davomida, keyin esa (leykotsitlar miqdori barqarorlashgach) 2 haftada bir marta; immunofan 0.005% - 1.0 m/o kun aro №5. Polivitaminlarni mikroelementlar bilan birgalikda qabul qilishni tasdiqlaydi.

Ключевые слова

Cherdja-Stross sindromi, ташхислаш, a’zolar va tizimlarni zararlanishi, gemogramma, miyelogramma, gormonlar bilan даволаш.

Литературы

1. Zakharova E.V. ANCA-associated vasculitis and cryoglobulinemic: diagnosis and treatment (review of literature). Nephrology and Dialysis. 2005; 1: 6-25 [In Russian]. 2. Masi A.T., Hunder G.G., Lie J.T., et al. The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis). Arthritis Rheum. 1990; 33: 1094–100. 3. Vorobyѐv A.I. Rukovodstvo po gematologii. Izdaniye tretye v 3-x t. – T. 1. – M.: Nyudiamed, 2002. – 280 s. 4. Fedoseyev G.B. Allergologiya. Chastnaya allergologiya. – T. 2. – SPb.: Nordmedizdat. – 2001. – 464 s. 5. Cohen P., Pagnoux C., Mahr A. et al. Treatment of Churg-Strauss syndrome (CSS) without poor prognostic factor at baseline with corticosteroids (CS) alone: Preliminary results of a prospective multicenter trial // Arthritis Rheum. — 2003. — V. 48. — P. 209. 6. Guillevin L., Cohen P., Gayraud M. et al. Churg-Strauss syndrome: Clinical study and longterm follow-up of 96 patients // Medicine (Baltimore). — 1999. — V. 78. — P. 26–37. 7. Katzenstein A.L. Diagnostic features and differential diagnosis of ChurgStrauss syndrome in the lung: A review // Am. J. Clin. Pathol. — 2000. — V. 114. — P. 767–772. (75) 8. Masi A.T., Hunder G.G., Lie J.T. et al. The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis) // Arthritis Rheum. — 1990. — V. 33. — P. 1094–1100.(83). 9. Abdiev K.M, et al. Modern methods of treatment of hemorrhagic syndrome at an early stage in patients with idiopathic thrombocytopenic purpura // Ученый XXI века — 2021, — № 1- 1—P. 41–44 (72). 10. Abdiev K.M, et al. Comparative evaluatation of new treatments for immune thrombocytopenia // Nat. Volatiles & Essent. Oils, 2021; 8(5): 10160 – 10166.