Kardiorespirator tadqiqotlar jurnali. Maxsus son. 2022
Тема статьи
EFFICACY OF AMLODIPINE IN ARTERIAL HYPERTENSION COMBINED WITH TYPE 2 DIABETES MELLITUS (114-117)
Авторы
Normatov M.B.
Учреждение
Samarkand State Medical Univercity
Аннотация
The combination of AH and diabetes increases the risk of coronary heart disease, stroke, kidney failure by 2-3 times. Therefore, it is extremely important to recognize and diagnose both arterial hypertension and diabetes mellitus early, in order to prescribe the appropriate treatment in time and stop the development of severe vascular complications. On the ionic level, insulin affects the entry of calcium and sodium into the cell, which affect the contractility of vascular smooth muscle fibers. As a result of decreased insulin sensitivity, calcium influx into the cell increases and smooth muscle cell tension increases. In such patients, the response of coronary arteries to physiological stimuli is reduced (decreased ability to dilate), which leads to impaired microcirculation.
Ключевые слова
Arterial hypertension, amlodipine, type 2 diabetes mellitus
Литературы
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